| Literature DB >> 10640697 |
S F Ali1, N Thiriet, J Zwiller.
Abstract
The aim of the present study was to evaluate if an acute injection of ibogaine (IBO) induces immediate early gene expression in different regions of mouse brain. Adult male C57 mice received a single injection of IBO and were perfused transcardially with 1% paraformaldehyde 30 min after the drug administration. A single injection of IBO produced a significant increase of egr-1 messenger RNA induction in nucleus accumbens (NAc), caudate-putamen (CPu), frontal cortex (FCx), septum, dentate gyrus (DG) and CA3 region of hippocampus, whereas c-fos gene was induced in CPu, FCx, DG, septum and CA1 region of hippocampus. This gene expression may be due, in part, to the stimulant properties of IBO, as we found with other psychostimulants.Entities:
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Year: 1999 PMID： 10640697 DOI： 10.1016/s0169-328x(99)00283-1
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X