Literature DB >> 10640637

Human midbrain dopamine neurons express serotonin 2A receptor: an immunohistochemical demonstration.

K Ikemoto1, A Nishimura, N Okado, M Mikuni, K Nishi, I Nagatsu.   

Abstract

We demonstrated intense serotonin (5-HT) 2A receptor immunoreactivity in the human ventral tegmental area (VTA) using by a recently raised antibody against 5-HT2A receptor. The substantia nigra (SN) neurons also showed 5-HT2A receptor immunoreactivity. Double immunohistochemistry of 5-HT2A receptor and tyrosine hydroxylase (TH) revealed many neurons doubly labeled by 5-HT2A receptor and TH in the VTA and SN. It is suggested that activity of human midbrain dopaminergic neurons might be strongly regulated via 5-HT2A receptors at the level of their originating nuclei.

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Year:  2000        PMID： 10640637     DOI： 10.1016/s0006-8993(99)02237-4

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

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7.  Dopamine neurons in the ventral tegmental area: an autopsy case of disorganized type of schizophrenia.

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  8 in total

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