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Literature DB >> 1064048

Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops.

Abstract

To evaluate a possible role for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] and adenosine 3':5'-cyclic monophosphate in the secretion of endolymph, we studied the effect of an intra-scala media injection of purified cholera toxin (an adenylate cyclase stimulant) on cochlear endolymph volume, endolymphatic potential, and endolymphatic Na and K concentrations.

Entities: Chemical Disease Gene

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Year: 1976 PMID： 1064048 PMCID： PMC430381 DOI： 10.1073/pnas.73.5.1761

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

22 in total

1. Action of cholera toxin to stimulate adenyl cyclase.

Authors: G W Sharp; S Hynie; L C Lipson; D K Parkinson
Journal: Trans Assoc Am Physicians Date: 1971

2. Role of cyclic AMP in the action of neurohypophyseal hormones on kidney.

Authors: T P Dousa; R Walter; I L Schwartz; H Sands; O Hechter
Journal: Adv Cyclic Nucleotide Res Date: 1972

3. Induction of steroidogenesis in tissue culture by cholera enterotoxin.

Authors: S T Donta; M King; K Sloper
Journal: Nat New Biol Date: 1973-06-20

4. Selective effects of cholera toxin on the adrenaline responsive component of hepatic adenyl cyclase.

Authors: R E Gorman; M W Bitensky
Journal: Nature Date: 1972-02-25 Impact factor: 49.962

5. The effect of catecholamine analogues upon amylase secretion from the mouse parotid gland in vivo:relationship to changes in cyclic AMP and cyclic GMP levels.

Authors: J P Durham; F R Butcher
Journal: FEBS Lett Date: 1974-10-15 Impact factor: 4.124

6. Stimulation of intestinal adenyl cyclase by cholera toxin.

Authors: G W Sharp; S Hynie
Journal: Nature Date: 1971-01-22 Impact factor: 49.962

7. Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase.

Authors: H R Bourne; R I Lehrer; L M Lichtenstein; G Weissmann; R Zurier
Journal: J Clin Invest Date: 1973-03 Impact factor: 14.808

8. The effect of cyclic AMP and dibutyryl cyclic AMP on the permeability characteristics of the renal tubule.

Authors: W B Lorentz
Journal: J Clin Invest Date: 1974-05 Impact factor: 14.808

9. Adenosine 3',5'-monophosphate (cyclic AMP) as the intracellular mediator of the action of secretin on the exocrine pancreas.

Authors: R M Case; T J Laundy; T Scratcherd
Journal: J Physiol Date: 1969-09 Impact factor: 5.182

10. The similarity of effects of vasopressin, adenosine-3',5'-phosphate (cyclic AMP) and theophylline on the toad bladder.

Authors: J ORLOFF; J S HANDLER
Journal: J Clin Invest Date: 1962-04 Impact factor: 14.808

7 in total

Effects of cholera toxin on cochlear endolymph production: model for endolymphatic hydrops.

1. Action of cholera toxin to stimulate adenyl cyclase.

2. Role of cyclic AMP in the action of neurohypophyseal hormones on kidney.

3. Induction of steroidogenesis in tissue culture by cholera enterotoxin.

4. Selective effects of cholera toxin on the adrenaline responsive component of hepatic adenyl cyclase.

5. The effect of catecholamine analogues upon amylase secretion from the mouse parotid gland in vivo:relationship to changes in cyclic AMP and cyclic GMP levels.

6. Stimulation of intestinal adenyl cyclase by cholera toxin.

7. Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase.

8. The effect of cyclic AMP and dibutyryl cyclic AMP on the permeability characteristics of the renal tubule.

9. Adenosine 3',5'-monophosphate (cyclic AMP) as the intracellular mediator of the action of secretin on the exocrine pancreas.

10. The similarity of effects of vasopressin, adenosine-3',5'-phosphate (cyclic AMP) and theophylline on the toad bladder.

1. Influence of "loop" diuretics upon Na+K+-ATPase and adenylate cyclase of the stria vascularis.

2. Adenylate cyclase and G-proteins as a signal transfer system in the guinea pig inner ear.

3. Histopathology of Meniere's disease.

4. Antidiuretic hormone stimulation of adenylate cyclase in semicircular canal epithelium.

Review 5. Endolymphatic hydrops: pathophysiology and experimental models.

6. Antidiuretic hormone restores the endolymphatic longitudinal K+ gradient in the Brattleboro rat cochlea.

Review 7. The adenylate cyclase receptor complex and aqueous humor formation.