| Literature DB >> 10640151 |
B Guillaume1, G Ameye, J M Libouton, J Dierlamm, J L Vaerman, N Straetmans, A Ferrant, C Verellen-Dumoulin, L Michaux.
Abstract
A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is reported. For the first time, this translocation has been characterized by fluorescence in situ hybridization (FISH) and the reverse transcriptase polymerase chain reaction (RT-PCR). FISH, with the use of whole-chromosome painting probes and probes specific for the BCR and ABL genes, showed a three-way variant Philadelphia translocation (9;22;21)(q34;q11;q22) with a BCR/ABL fusion residing on the der(22). In addition, RT-PCR demonstrated a b2a3 BCR/ABL fusion transcript. Underlying mechanisms and prognostic implications are discussed.Entities:
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Year: 2000 PMID： 10640151 DOI： 10.1016/s0165-4608(99)00115-6
Source DB: PubMed Journal: Cancer Genet Cytogenet ISSN： 0165-4608