RATIONALE: Previous research suggests that glucose may reduce desire to smoke during periods of abstinence but a definitive test is needed. OBJECTIVE: The present study aimed to determine whether a single administration of oral glucose would reduce desire to smoke in abstaining smokers. METHODS:Thirty-eight smokers attended the laboratory in the afternoon having not smoked since the previous evening. They rated their desire to smoke immediately before and at 5-min intervals for 20 min after chewing four 3-g glucose tablets (experimental group) or four matched placebo tablets (control group). RESULTS:Ratings of desire to smoke decreased to a greater extent in the experimental than the control group. The effect was apparent after 10 min. There was no difference between the groups in terms of feeling "sick" or "satisfied". CONCLUSION: A single dose of glucose has a relatively rapid and detectable effect on desire to smoke and the effect is not mediated by feeling sick. Glucose tablets may be useful in helping to control desire to smoke during periods of abstinence.
RCT Entities:
RATIONALE: Previous research suggests that glucose may reduce desire to smoke during periods of abstinence but a definitive test is needed. OBJECTIVE: The present study aimed to determine whether a single administration of oral glucose would reduce desire to smoke in abstaining smokers. METHODS: Thirty-eight smokers attended the laboratory in the afternoon having not smoked since the previous evening. They rated their desire to smoke immediately before and at 5-min intervals for 20 min after chewing four 3-g glucose tablets (experimental group) or four matched placebo tablets (control group). RESULTS: Ratings of desire to smoke decreased to a greater extent in the experimental than the control group. The effect was apparent after 10 min. There was no difference between the groups in terms of feeling "sick" or "satisfied". CONCLUSION: A single dose of glucose has a relatively rapid and detectable effect on desire to smoke and the effect is not mediated by feeling sick. Glucose tablets may be useful in helping to control desire to smoke during periods of abstinence.
Authors: Benjamin A Toll; Marney White; Ran Wu; Boris Meandzija; Peter Jatlow; Robert Makuch; Stephanie S O'Malley Journal: Drug Alcohol Depend Date: 2010-06-12 Impact factor: 4.492
Authors: Rachna Begh; Marcus R Munafò; Saul Shiffman; Stuart G Ferguson; Linda Nichols; Mohammed A Mohammed; Roger L Holder; Stephen Sutton; Paul Aveyard Journal: Drug Alcohol Depend Date: 2015-02-09 Impact factor: 4.492
Authors: Michael Ussher; Paul Aveyard; Fiona Reid; Robert West; Phil Evans; Angela Clow; Frank Hucklebridge; Julie Fuller; Judith Ibison; Andrew Steptoe Journal: Psychopharmacology (Berl) Date: 2011-02-09 Impact factor: 4.530