Literature DB >> 10639465

Identification of the operon for the sorbitol (Glucitol) Phosphoenolpyruvate:Sugar phosphotransferase system in Streptococcus mutans.

D A Boyd1, T Thevenot, M Gumbmann, A L Honeyman, I R Hamilton.   

Abstract

Transposon mutagenesis and marker rescue were used to isolate and identify an 8.5-kb contiguous region containing six open reading frames constituting the operon for the sorbitol P-enolpyruvate phosphotransferase transport system (PTS) of Streptococcus mutans LT11. The first gene, srlD, codes for sorbitol-6-phosphate dehydrogenase, followed downstream by srlR, coding for a transcriptional regulator; srlM, coding for a putative activator; and the srlA, srlE, and srlB genes, coding for the EIIC, EIIBC, and EIIA components of the sorbitol PTS, respectively. Among all sorbitol PTS operons characterized to date, the srlD gene is found after the genes coding for the EII components; thus, the location of the gene in S. mutans is unique. The SrlR protein is similar to several transcriptional regulators found in Bacillus spp. that contain PTS regulator domains (J. Stülke, M. Arnaud, G. Rapoport, and I. Martin-Verstraete, Mol. Microbiol. 28:865-874, 1998), and its gene overlaps the srlM gene by 1 bp. The arrangement of these two regulatory genes is unique, having not been reported for other bacteria.

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Year:  2000        PMID： 10639465      PMCID： PMC97224          DOI： 10.1128/IAI.68.2.925-930.2000

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  32 in total

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Review 2.  Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.

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3.  A gene system for glucitol transport and metabolism in Clostridium beijerinckii NCIMB 8052.

Authors:  M Tangney; J K Brehm; N P Minton; W J Mitchell
Journal:  Appl Environ Microbiol       Date:  1998-05       Impact factor: 4.792

4.  Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping.

Authors:  J Lengeler
Journal:  J Bacteriol       Date:  1975-10       Impact factor: 3.490

5.  Genetic transformation of putative cariogenic properties in Streptococcus mutans.

Authors:  D Perry; L M Wondrack; H K Kuramitsu
Journal:  Infect Immun       Date:  1983-08       Impact factor: 3.441

Review 6.  The phosphoenolpyruvate:sugar phosphotransferase system of oral streptococci and its role in the control of sugar metabolism.

Authors:  C Vadeboncoeur; M Pelletier
Journal:  FEMS Microbiol Rev       Date:  1997-02       Impact factor: 16.408

7.  Genetics of sorbitol metabolism in Erwinia amylovora and its influence on bacterial virulence.

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8.  Cloning, expression, and isolation of the mannitol transport protein from the thermophilic bacterium Bacillus stearothermophilus.

Authors:  S A Henstra; B Tolner; R H ten Hoeve Duurkens; W N Konings; G T Robillard
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9.  Regulation of hexitol catabolism in Streptococcus mutans.

Authors:  S S Dills; S Seno
Journal:  J Bacteriol       Date:  1983-02       Impact factor: 3.490

Review 10.  PRD--a protein domain involved in PTS-dependent induction and carbon catabolite repression of catabolic operons in bacteria.

Authors:  J Stülke; M Arnaud; G Rapoport; I Martin-Verstraete
Journal:  Mol Microbiol       Date:  1998-06       Impact factor: 3.501
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  11 in total

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Authors:  J E van Hylckama Vlieg; L Tang; J H Lutje Spelberg; T Smilda; G J Poelarends; T Bosma; A E van Merode; M W Fraaije; D B Janssen
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4.  Utilization of lactose and galactose by Streptococcus mutans: transport, toxicity, and carbon catabolite repression.

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5.  The doubly phosphorylated form of HPr, HPr(Ser~P)(His-P), is abundant in exponentially growing cells of Streptococcus thermophilus and phosphorylates the lactose transporter LacS as efficiently as HPr(His~P).

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7.  Cloning, purification and characterization of an NAD-Dependent D-Arabitol dehydrogenase from acetic acid bacterium, Acetobacter suboxydans.

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8.  A mariner transposon vector adapted for mutagenesis in oral streptococci.

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10.  Identification and functional analysis of the L-ascorbate-specific enzyme II complex of the phosphotransferase system in Streptococcus mutans.

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