Literature DB >> 10639374

Role of the PDR gene network in yeast susceptibility to the antifungal antibiotic mucidin.

D Michalkova-Papajova1, M Obernauerova, J Subik.   

Abstract

Yeast strains disrupted in the PDR1, PDR3, or PDR5 gene, but not in SNQ2, exhibited higher sensitivity to mucidin (strobilurin A) than did the isogenic wild-type strains. Different gain-of-function mutations in the PDR1 and PDR3 genes rendered yeast mutants resistant to this antibiotic. Mucidin induced PDR5 expression, but the changes in the expression of SNQ2 were only barely detectable. The results indicate that PDR5 provides the link between transcriptional regulation by PDR1 and PDR3 and mucidin resistance of yeast.

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Year:  2000        PMID： 10639374      PMCID： PMC89695          DOI： 10.1128/AAC.44.2.418-420.2000

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

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Authors:  D Sanglard; F Ischer; D Calabrese; M Micheli; J Bille
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Review 2.  Active efflux by multidrug transporters as one of the strategies to evade chemotherapy and novel practical implications of yeast pleiotropic drug resistance.

Authors:  M Kolaczkowski; A Goffeau
Journal:  Pharmacol Ther       Date:  1997 Oct-Dec       Impact factor: 12.310

3.  Antibiotic mucidin, a new antimycin A-like inhibitor of electron transport in rat liver mitochondria.

Authors:  J Subík; M Behún; V Musílek
Journal:  Biochem Biophys Res Commun       Date:  1974-03-15       Impact factor: 3.575

4.  Genetic mapping of nuclear mucidin resistance mutations in Saccharomyces cerevisiae. A new pdr locus on chromosome II.

Authors:  J Subik; S Ulaszewski; A Goffeau
Journal:  Curr Genet       Date:  1986       Impact factor: 3.886

5.  The involvement of the Saccharomyces cerevisiae multidrug resistance transporters Pdr5p and Snq2p in cation resistance.

Authors:  K Miyahara; M Mizunuma; D Hirata; E Tsuchiya; T Miyakawa
Journal:  FEBS Lett       Date:  1996-12-16       Impact factor: 4.124

6.  Clustered amino acid substitutions in the yeast transcription regulator Pdr3p increase pleiotropic drug resistance and identify a new central regulatory domain.

Authors:  A Nourani; D Papajova; A Delahodde; C Jacq; J Subik
Journal:  Mol Gen Genet       Date:  1997-10

7.  Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes.

Authors:  E Carvajal; H B van den Hazel; A Cybularz-Kolaczkowska; E Balzi; A Goffeau
Journal:  Mol Gen Genet       Date:  1997-10

8.  The multidrug resistance-associated protein (MRP) subfamily (Yrs1/Yor1) of Saccharomyces cerevisiae is important for the tolerance to a broad range of organic anions.

Authors:  Z Cui; D Hirata; E Tsuchiya; H Osada; T Miyakawa
Journal:  J Biol Chem       Date:  1996-06-21       Impact factor: 5.157

9.  yAP-1- and yAP-2-mediated, heat shock-induced transcriptional activation of the multidrug resistance ABC transporter genes in Saccharomyces cerevisiae.

Authors:  K Miyahara; D Hirata; T Miyakawa
Journal:  Curr Genet       Date:  1996-01       Impact factor: 3.886

10.  The pdr12 ABC transporter is required for the development of weak organic acid resistance in yeast.

Authors:  P Piper; Y Mahé; S Thompson; R Pandjaitan; C Holyoak; R Egner; M Mühlbauer; P Coote; K Kuchler
Journal:  EMBO J       Date:  1998-08-03       Impact factor: 11.598
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  3 in total

1.  Genome-wide expression patterns in Saccharomyces cerevisiae: comparison of drug treatments and genetic alterations affecting biosynthesis of ergosterol.

Authors:  G F Bammert; J M Fostel
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

2.  Antifungal activity of redox-active benzaldehydes that target cellular antioxidation.

Authors:  Jong H Kim; Kathleen L Chan; Noreen Mahoney; Bruce C Campbell
Journal:  Ann Clin Microbiol Antimicrob       Date:  2011-05-31       Impact factor: 3.944

3.  Cross-resistance to strobilurin fungicides in mitochondrial and nuclear mutants of Saccharomyces cerevisiae.

Authors:  M Hnátová; Y Gbelská; M Obernauerová; V Subíková; J Subík
Journal:  Folia Microbiol (Praha)       Date:  2003       Impact factor: 2.629
  3 in total

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