Literature DB >> 10639019

Isolation and structure elucidation of new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa.

L Garrido1, E Zubía, M J Ortega, J Salvá.   

Abstract

The gorgonian Leptogorgia sarmentosa contains three new steroids, (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)-16,20-dihydroxycholestan-3-one (2), and (20S)-20-hydroxycholest-1-ene-3,16-dione (3) together with a known related compound (4). Their structures were defined by spectroscopic analysis. The new steroids exhibited significant cytotoxicity against four tumor cell lines (ED50 = 1 microg/ml).

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Year:  2000        PMID： 10639019     DOI： 10.1016/s0039-128x(99)00083-5

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  5 in total

1.  Antiprotozoan activity of Brazilian marine cnidarian extracts and of a modified steroid from the octocoral Carijoa riisei.

Authors:  Juliana Quero Reimão; Alvaro Esteves Migotto; Miriam H Kossuga; Roberto G S Berlinck; André Gustavo Tempone
Journal:  Parasitol Res       Date:  2008-09-02       Impact factor: 2.289

Review 2.  A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010.

Authors:  Marc Schumacher; Mareike Kelkel; Mario Dicato; Marc Diederich
Journal:  Molecules       Date:  2011-06-30       Impact factor: 4.411

Review 3.  Cytotoxic and cytolytic cnidarian venoms. A review on health implications and possible therapeutic applications.

Authors:  Gian Luigi Mariottini; Luigi Pane
Journal:  Toxins (Basel)       Date:  2013-12-27       Impact factor: 4.546

4.  Polyoxygenated steroids from the octocoral Leptogorgia punicea and in vitro evaluation of their cytotoxic activity.

Authors:  Maria Izabel G Moritz; Lucas Lourenço Marostica; Everson M Bianco; Maria Tereza R Almeida; João L Carraro; Gabriela M Cabrera; Jorge A Palermo; Cláudia M O Simões; Eloir P Schenkel
Journal:  Mar Drugs       Date:  2014-12-04       Impact factor: 5.118

5.  Leptogorgins A-C, Humulane Sesquiterpenoids from the Vietnamese Gorgonian Leptogorgia sp.

Authors:  Irina I Kapustina; Tatyana N Makarieva; Alla G Guzii; Anatoly I Kalinovsky; Roman S Popov; Sergey A Dyshlovoy; Boris B Grebnev; Gunhild von Amsberg; Valentin A Stonik
Journal:  Mar Drugs       Date:  2020-06-13       Impact factor: 5.118
  5 in total

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