Literature DB >> 10638971

Antibodies to heat shock protein 90 in osteosarcoma patients correlate with response to neoadjuvant chemotherapy.

K Trieb1, R Gerth, G Holzer, J G Grohs, P Berger, R Kotz.   

Abstract

Autoantibodies to the heat shock protein 90 (Hsp 90) have been reported as prognostic marker in breast cancer patients. Sera from 20 high-grade osteosarcoma patients were tested at the time of diagnosis by enzyme-linked immunosorbent assay. Presence of anti-Hsp90 antibodies correlated with a better response to neoadjuvant chemotherapy (P < 0.01), whereas the absence correlated with development of metastases. These data suggest that anti-Hsp90 antibodies might be of predictive value in human osteosarcoma.

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Year:  2000        PMID： 10638971      PMCID： PMC2363193          DOI： 10.1054/bjoc.1999.0881

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  14 in total

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Journal:  Cell Stress Chaperones       Date:  2018-09-05       Impact factor: 3.667

2.  Monitoring the induction of heat shock factor 1/heat shock protein 70 expression following 17-allylamino-demethoxygeldanamycin treatment by positron emission tomography and optical reporter gene imaging.

Authors:  Mikhail Doubrovin; Jian T Che; Inna Serganova; Ekaterina Moroz; David B Solit; Lyudmila Ageyeva; Tatiana Kochetkova; Nagavarakishore Pillarsetti; Ronald Finn; Neal Rosen; Ronald G Blasberg
Journal:  Mol Imaging       Date:  2012-02       Impact factor: 4.488

3.  Pre-operative serum C-reactive protein as independent prognostic factor for survival but not infection in patients with high-grade osteosarcoma.

Authors:  Philipp T Funovics; Gundula Edelhauser; Martin A Funovics; Christoph Laux; Dominik Berzaczy; Bernd Kubista; Rainer I Kotz; Martin Dominkus
Journal:  Int Orthop       Date:  2011-01-21       Impact factor: 3.075

Review 4.  Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications.

Authors:  Daniel R Ciocca; Stuart K Calderwood
Journal:  Cell Stress Chaperones       Date:  2005       Impact factor: 3.667

5.  Heat shock protein expression analysis in canine osteosarcoma reveals HSP60 as a potentially relevant therapeutic target.

Authors:  Gayathri T Selvarajah; Floor A S Bonestroo; Jolle Kirpensteijn; Marja J L Kik; Ruurd van der Zee; Willem van Eden; Elpetra P M Timmermans-Sprang; Adri Slob; Jan A Mol
Journal:  Cell Stress Chaperones       Date:  2013-03-06       Impact factor: 3.667

6.  Livin and Bcl-2 expression in high-grade osteosarcoma.

Authors:  T Nedelcu; B Kubista; A Koller; I Sulzbacher; I Mosberger; F Arrich; K Trieb; R Kotz; C D Toma
Journal:  J Cancer Res Clin Oncol       Date:  2007-07-14       Impact factor: 4.553

7.  Anti-HSP90 autoantibodies in sera of infertile women identify a dominant, conserved epitope EP6 (380-389) of HSP90 beta protein.

Authors:  Eusebio S Pires; Asmita K Choudhury; Susan Idicula-Thomas; Vrinda V Khole
Journal:  Reprod Biol Endocrinol       Date:  2011-01-27       Impact factor: 5.211

8.  Recurrence rate and progression of chondrosarcoma is correlated with heat shock protein expression.

Authors:  Klemens Trieb; Irene Sulzbacher; Bernd Kubista
Journal:  Oncol Lett       Date:  2015-11-17       Impact factor: 2.967

9.  The double-edged sword: conserved functions of extracellular hsp90 in wound healing and cancer.

Authors:  Michael W Hance; Krystal D Nolan; Jennifer S Isaacs
Journal:  Cancers (Basel)       Date:  2014-05-06       Impact factor: 6.639

10.  Identification of heat shock protein 90 and other proteins as tumour antigens by serological screening of an ovarian carcinoma expression library.

Authors:  L-Y Luo; I Herrera; A Soosaipillai; E P Diamandis
Journal:  Br J Cancer       Date:  2002-07-29       Impact factor: 7.640
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