Prenatal morphine exposure alters N-methyl-D-aspartate- and kainate-induced seizures in adult male rats.

The purpose of the present study was to investigate whether prenatal exposure to morphine has effects on excitatory amino acid-induced seizures. Adult male rats, exposed on embryonic days 11-18 to saline or morphine, were injected with N-methyl-D-aspartate (NMDA) (150, 175, 200, 225, and 250 mg/kg) or kainic acid (KA) (15 or 20 mg/kg) in adulthood to assess the occurrence and latency to onset of stereotypy and seizures. The latency to onset of stereotypy was significantly increased after 175 mg/kg, and decreased after 200 mg/kg of NMDA in morphine-exposed animals. The lowest dose of NMDA (150 mg/kg) induced seizures in prenatally saline-treated control male rats but not in the morphine-exposed male rats. In the KA-injected group, prenatally morphine-exposed males had shorter latency to onset of wet-dog shakes, but there were no effects on the latency to onset of clonic seizures. The data suggest that prenatal morphine exposure has long-term effects on seizure susceptibility and the onset of stereotypy in the excitatory amino acid-induced seizure models.