Literature DB >> 10637649

5-HT modifiers as a potential treatment of asthma.

I Cazzola1, M G Matera.   

Abstract

Increased levels of free 5-HT have been shown to be present in the plasma of symptomatic asthmatic patients compared with levels in asymptomatic patients. In addition, free 5-HT has been shown to correlate positively with clinical status and negatively with pulmonary function. These findings suggest that 5-HT might play a role in the pathophysiology of acute asthma. Accordingly, modifiers of the 5-HT transmitter system such as compounds that affect the 5-HT transporter, prejunctional 5-HT receptors or postsynaptic 5-HT receptors might represent a novel treatment of asthma.

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Year:  2000        PMID： 10637649     DOI： 10.1016/s0165-6147(99)01408-x

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  18 in total

1.  Allergen and ozone exacerbate serotonin-induced increases in airway smooth muscle contraction in a model of childhood asthma.

Authors:  Brian D Moore; Dallas Hyde; Lisa Miller; Emily Wong; Jessica Frelinger; Edward S Schelegle
Journal:  Respiration       Date:  2012-04-13       Impact factor: 3.580

2.  Effect of serotonin on the differentiation of human monocytes into dendritic cells.

Authors:  N Katoh; F Soga; T Nara; R Tamagawa-Mineoka; M Nin; H Kotani; K Masuda; S Kishimoto
Journal:  Clin Exp Immunol       Date:  2006-11       Impact factor: 4.330

3.  Role of meconium in the reaction of airways smooth musculature in the newborn with meconium aspiration syndrome (MAS).

Authors:  Hilmi Islami; Sadi Bexheti; Ragip Shabani; Bajram Nuraj; Fehmi Zeqiri; Aziz Sukalo; Ilir Kurtishi; Skender Kutllovci; Hasime Qorraj; Mentor Disha
Journal:  Bosn J Basic Med Sci       Date:  2009-11       Impact factor: 3.363

4.  Inhibition of allergic inflammation by supplementation with 5-hydroxytryptophan.

Authors:  Hiam Abdala-Valencia; Sergejs Berdnikovs; Christine A McCary; Daniela Urick; Riti Mahadevia; Michelle E Marchese; Kelsey Swartz; Lakiea Wright; Gökhan M Mutlu; Joan M Cook-Mills
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2012-07-27       Impact factor: 5.464

5.  Activation of mouse bronchopulmonary C-fibres by serotonin and allergen-ovalbumin challenge.

Authors:  Carl Potenzieri; Sonya Meeker; Bradley J Undem
Journal:  J Physiol       Date:  2012-08-20       Impact factor: 5.182

6.  Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea.

Authors:  James D Moffatt; Thomas M Cocks; Clive P Page
Journal:  Br J Pharmacol       Date:  2004-03-15       Impact factor: 8.739

7.  Role of the serotonergic system in reduced pulmonary function after exposure to methamphetamine.

Authors:  Sandra M Wells; Mary C Buford; Virginia M Porter; Heather L Brunell; Melisa Bunderson-Schelvan; Andrew B Nevin; Fernando Cardozo-Pelaez; Andrij Holian
Journal:  Am J Respir Cell Mol Biol       Date:  2009-06-18       Impact factor: 6.914

8.  Ozone exposure alters serotonin and serotonin receptor expression in the developing lung.

Authors:  Shannon R Murphy; Edward S Schelegle; Lisa A Miller; Dallas M Hyde; Laura S Van Winkle
Journal:  Toxicol Sci       Date:  2013-04-09       Impact factor: 4.849

9.  Chemosensory functions for pulmonary neuroendocrine cells.

Authors:  Xiaoling Gu; Philip H Karp; Steven L Brody; Richard A Pierce; Michael J Welsh; Michael J Holtzman; Yehuda Ben-Shahar
Journal:  Am J Respir Cell Mol Biol       Date:  2014-03       Impact factor: 6.914

10.  A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children.

Authors:  Gehan Ahmed Mostafa; Laila Yousef Al-Ayadhi
Journal:  J Neuroinflammation       Date:  2011-06-22       Impact factor: 8.322
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