AIM: To compare the QT dispersion in unselected patients with insulin-dependent diabetes mellitus to non-diabetic control subjects and to assess the association between the QT dispersion and cardiac autonomic neuropathy, ischaemic heart disease, blood pressure level and nephropathy. METHODS: 42 patients with insulin-dependent diabetes mellitus and 80 control subjects aged 40-57 years participated. The QT interval was measured in a resting 12-lead electrocardiogram (ECG) and the QT dispersion defined as the difference between the maximum and minimum QT interval. Bazett's formula was used to correct for heart rate (QTc). The degree of cardiac autonomic neuropathy was assessed by five function tests and ischaemic heart disease was defined by a previous myocardial infarction, ECG abnormalities or a positive exercise test. RESULTS: Compared to control subjects, diabetic patients had a longer QTc interval (433 vs. 416 ms; P=0.002) and a higher QT dispersion (36 vs. 30 ms; P=0.02). In the diabetic group, the QTc interval was prolonged in patients with autonomic neuropathy (449 vs. 420 ms; P=0.007) and the QT dispersion was increased in patients with ischaemic heart disease (51 vs. 33 ms; P=0.004). No association was found to urinary albumin excretion rate or blood pressure. CONCLUSION: The QT dispersion as well as the QTc interval is increased in patients with insulin-dependent diabetes mellitus. The association between QT dispersion and ischaemic heart disease indicates that abnormalities in cardiac repolarisation may be caused by complications to diabetes rather than diabetes in itself.
AIM: To compare the QT dispersion in unselected patients with insulin-dependent diabetes mellitus to non-diabetic control subjects and to assess the association between the QT dispersion and cardiac autonomic neuropathy, ischaemic heart disease, blood pressure level and nephropathy. METHODS: 42 patients with insulin-dependent diabetes mellitus and 80 control subjects aged 40-57 years participated. The QT interval was measured in a resting 12-lead electrocardiogram (ECG) and the QT dispersion defined as the difference between the maximum and minimum QT interval. Bazett's formula was used to correct for heart rate (QTc). The degree of cardiac autonomic neuropathy was assessed by five function tests and ischaemic heart disease was defined by a previous myocardial infarction, ECG abnormalities or a positive exercise test. RESULTS: Compared to control subjects, diabeticpatients had a longer QTc interval (433 vs. 416 ms; P=0.002) and a higher QT dispersion (36 vs. 30 ms; P=0.02). In the diabetic group, the QTc interval was prolonged in patients with autonomic neuropathy (449 vs. 420 ms; P=0.007) and the QT dispersion was increased in patients with ischaemic heart disease (51 vs. 33 ms; P=0.004). No association was found to urinary albumin excretion rate or blood pressure. CONCLUSION: The QT dispersion as well as the QTc interval is increased in patients with insulin-dependent diabetes mellitus. The association between QT dispersion and ischaemic heart disease indicates that abnormalities in cardiac repolarisation may be caused by complications to diabetes rather than diabetes in itself.
Authors: Ederson Evaristo; Fernando G Stocco; Nishant R Shah; Michael K Cheezum; Jon Hainer; Courtney Foster; Bruce D Nearing; Marcelo Di Carli; Richard L Verrier Journal: Ann Noninvasive Electrocardiol Date: 2017-06-27 Impact factor: 1.468
Authors: N P Murphy; M E Ford-Adams; K K Ong; N D Harris; S M Keane; C Davies; R H Ireland; I A MacDonald; E J Knight; J A Edge; S R Heller; D B Dunger Journal: Diabetologia Date: 2004-11-17 Impact factor: 10.122
Authors: Pınar Yeşim Akyol; Hüseyin Acar; Adem Çakır; Yusuf Şahin; Zeynep Karakaya; Fatih Esad Topal Journal: Biomed Res Int Date: 2021-11-24 Impact factor: 3.411