| Literature DB >> 10636249 |
T Lu1, R M Soll, C R Illig, R Bone, L Murphy, J Spurlino, F R Salemme, B E Tomczuk.
Abstract
The structure activity relationships of a novel series of non-amide-based thrombin inhibitors are described. Exploration of the P2 and the aryl binding region for this series has identified optimal groups for achieving nanomolar potency. The binding modes of these optimal groups have been confirmed by X-ray structural analysis.Entities:
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Year: 2000 PMID： 10636249 DOI： 10.1016/s0960-894x(99)00617-4
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823