Literature DB >> 10636243

Synthesis and binding studies of some epibatidine analogues.

S Rádl1, P Hezký, W Hafner, M Budesínský, L Hejnová.   

Abstract

A series of epibatidine analogues and their positional isomers bearing an 8-azabicyclo[3.2.1]octane moiety is described. Some of the compounds, especially those containing 8-azabicyclo[3.2.1]oct-2-ene moiety show high affinity for the nicotinic cholinergic receptor.

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Year:  2000        PMID： 10636243     DOI： 10.1016/s0960-894x(99)00575-2

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  N,N-disubstituted piperazines: synthesis and affinities at alpha4beta2(*) and alpha7(*) neuronal nicotinic acetylcholine receptors.

Authors:  Jianhong Chen; Seth Norrholm; Linda P Dwoskin; Peter A Crooks; Donglu Bai
Journal:  Bioorg Med Chem Lett       Date:  2003-01-06       Impact factor: 2.823

2.  Design, synthesis, and biological activity of 5'-phenyl-1,2,5,6-tetrahydro-3,3'-bipyridine analogues as potential antagonists of nicotinic acetylcholine receptors.

Authors:  Yafei Jin; Xiaoqin Huang; Roger L Papke; Emily M Jutkiewicz; Hollis D Showalter; Chang-Guo Zhan
Journal:  Bioorg Med Chem Lett       Date:  2017-08-14       Impact factor: 2.823

Review 3.  Nicotinic agonists, antagonists, and modulators from natural sources.

Authors:  John W Daly
Journal:  Cell Mol Neurobiol       Date:  2005-06       Impact factor: 5.046
  3 in total

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