Literature DB >> 10636239

Design and synthesis of highly potent fumagillin analogues from homology modeling for a human MetAP-2.

C K Han1, S K Ahn, N S Choi, R K Hong, S K Moon, H S Chun, S J Lee, J W Kim, C I Hong, D Kim, J H Yoon, K T No.   

Abstract

New fumagillin analogues were designed through structure-based molecular modeling with a human methionine aminopeptidase-2. Among the fumagillin analogues, cinnamic acid ester derivative CKD-731 showed 1000-fold more potent proliferation inhibitory activity on endothelial cell than TNP-470.

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Year:  2000        PMID： 10636239     DOI： 10.1016/s0960-894x(99)00577-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Investigations into microsporidian methionine aminopeptidase type 2: a therapeutic target for microsporidiosis.

Authors:  Hong Zhang; Huan Huang; Ann Cali; Peter M Takvorian; Xiaochuan Feng; Ghou Zhou; Louis M Weiss
Journal:  Folia Parasitol (Praha)       Date:  2005-05       Impact factor: 2.122

2.  Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1.

Authors:  Y Zhang; E C Griffith; J Sage; T Jacks; J O Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  Diazo reagents with small steric footprints for simultaneous arming/SAR studies of alcohol-containing natural products via O-H insertion.

Authors:  Supakarn Chamni; Qing-Li He; Yongjun Dang; Shridhar Bhat; Jun O Liu; Daniel Romo
Journal:  ACS Chem Biol       Date:  2011-09-28       Impact factor: 5.100

4.  A single amino acid residue defines the difference in ovalicin sensitivity between type I and II methionine aminopeptidases.

Authors:  Cathleen M Brdlik; Craig M Crews
Journal:  J Biol Chem       Date:  2003-12-15       Impact factor: 5.157

5.  Discovery and SARs of trans-3-aryl acrylic acids and their analogs as novel anti-tobacco mosaic virus (TMV) agents.

Authors:  Meng Wu; Ziwen Wang; Chuisong Meng; Kailiang Wang; Yanna Hu; Lizhong Wang; Qingmin Wang
Journal:  PLoS One       Date:  2013-02-13       Impact factor: 3.240

Review 6.  Research progress in the biological activities of 3,4,5-trimethoxycinnamic acid (TMCA) derivatives.

Authors:  Zefeng Zhao; Huanhuan Song; Jing Xie; Tian Liu; Xue Zhao; Xufei Chen; Xirui He; Shaoping Wu; Yongmin Zhang; Xiaohui Zheng
Journal:  Eur J Med Chem       Date:  2019-04-06       Impact factor: 6.514
  6 in total

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