Literature DB >> 10636233

A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding assays.

D Y Maeda1, W Williams, W D Bowen, A Coop.   

Abstract

A simple, achiral monoamine sigma-1 (sigma1) receptor selective ligand (sigma2Ki/sigma1Ki>2000) is described, which could replace the chiral (+)-pentazocine or dextrallorphan as a sigma1 masking agent in sigma2 binding assays.

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Year:  2000        PMID： 10636233     DOI： 10.1016/s0960-894x(99)00590-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  A new method for evaluating sigma(2) ligand activity in the isolated guinea-pig bladder.

Authors:  Nicola A Colabufo; Francesco Berardi; Marialessandra Contino; Roberto Perrone; Vincenzo Tortorella
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2003-07-17       Impact factor: 3.000

2.  Synthesis and pharmacological evaluation of indole-based sigma receptor ligands.

Authors:  Christophe Mésangeau; Emanuele Amata; Walid Alsharif; Michael J Seminerio; Matthew J Robson; Rae R Matsumoto; Jacques H Poupaert; Christopher R McCurdy
Journal:  Eur J Med Chem       Date:  2011-08-29       Impact factor: 6.514

3.  Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines.

Authors:  Nicola Antonio Colabufo; Francesco Berardi; Marialessandra Contino; Mauro Niso; Carmen Abate; Roberto Perrone; Vincenzo Tortorella
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-07-31       Impact factor: 3.000

4.  From α4β2 Nicotinic Ligands to the Discovery of σ1 Receptor Ligands: Pharmacophore Analysis and Rational Design.

Authors:  Li-Fang Yu; Han-Kun Zhang; Hendra Gunosewoyo; Alan P Kozikowski
Journal:  ACS Med Chem Lett       Date:  2012-12-13       Impact factor: 4.345

Review 5.  Multi-Target Directed Ligands (MTDLs) Binding the σ1 Receptor as Promising Therapeutics: State of the Art and Perspectives.

Authors:  Francesca Serena Abatematteo; Mauro Niso; Marialessandra Contino; Marcello Leopoldo; Carmen Abate
Journal:  Int J Mol Sci       Date:  2021-06-14       Impact factor: 5.923
  5 in total

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