Literature DB >> 10636159

Serum cholesterol, APOE genotype, and the risk of Alzheimer's disease: a population-based study of African Americans.

R M Evans1, C L Emsley, S Gao, A Sahota, K S Hall, M R Farlow, H Hendrie.   

Abstract

A significant interaction among total serum cholesterol (TC), APOE genotype, and AD risk was found in a population-based study of elderly African Americans. Increasing TC was associated with increased AD risk in the group with no epsilon4 alleles, whereas TC was not associated with increased AD risk in the group with one or more epsilon4 alleles. Further study of the relationship between cholesterol and APOE genotype is needed to confirm this association, but the results suggest that cholesterol may be a potentially modifiable environmental risk factor for AD.

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Year:  2000        PMID： 10636159     DOI： 10.1212/wnl.54.1.240

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  66 in total

Review 1.  Type 2 diabetes mellitus, dyslipidemia, and Alzheimer's disease.

Authors:  Cynthia M Carlsson
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2.  Cholesterol, APOE genotype, and Alzheimer disease: an epidemiologic study of Nigerian Yoruba.

Authors:  K Hall; J Murrell; A Ogunniyi; M Deeg; O Baiyewu; S Gao; O Gureje; J Dickens; R Evans; V Smith-Gamble; F W Unverzagt; J Shen; H Hendrie
Journal:  Neurology       Date:  2006-01-24       Impact factor: 9.910

3.  Increased atherogenic lipoproteins are associated with cognitive impairment: effects of statins and subclinical atherosclerosis.

Authors:  Cynthia M Carlsson; David M Nondahl; Barbara E K Klein; Patrick E McBride; Mark A Sager; Carla R Schubert; Ronald Klein; Karen J Cruickshanks
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Review 4.  The effects of cholesterol on learning and memory.

Authors:  Bernard G Schreurs
Journal:  Neurosci Biobehav Rev       Date:  2010-05-12       Impact factor: 8.989

Review 5.  Biomarkers of Alzheimer disease in plasma.

Authors:  Michael C Irizarry
Journal:  NeuroRx       Date:  2004-04

6.  Alzheimer's Disease in Adults with Down Syndrome.

Authors:  Warren B Zigman; Darlynne A Devenny; Sharon J Krinsky-McHale; Edmund C Jenkins; Tiina K Urv; Jerzy Wegiel; Nicole Schupf; Wayne Silverman
Journal:  Int Rev Res Ment Retard       Date:  2008-01-01

7.  Low HDL cholesterol is a risk factor for deficit and decline in memory in midlife: the Whitehall II study.

Authors:  Archana Singh-Manoux; David Gimeno; Mika Kivimaki; Eric Brunner; Michael G Marmot
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Review 8.  Blood-based protein biomarkers for diagnosis and classification of neurodegenerative diseases: current progress and clinical potential.

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Journal:  Mol Diagn Ther       Date:  2011-04-01       Impact factor: 4.074

9.  Association of statin use with cognitive decline in elderly African Americans.

Authors:  S J Szwast; H C Hendrie; K A Lane; S Gao; S E Taylor; F Unverzagt; J Murrell; M Deeg; A Ogunniyi; M R Farlow; K S Hall
Journal:  Neurology       Date:  2007-11-06       Impact factor: 9.910

Review 10.  Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease.

Authors:  Mark Burns; Karen Duff
Journal:  Neurochem Res       Date:  2003-07       Impact factor: 3.996
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