Literature DB >> 10636156

Valproate-induced hyperammonemic encephalopathy in the presence of topiramate.

H M Hamer1, S Knake, U Schomburg, F Rosenow.   

Abstract

Two adult patients with focal epilepsy who tolerated valproate (VPA) well in different combinations of anticonvulsants developed hyperammonemic encephalopathy when treated with VPA in combination with topiramate (TPM). Topiramate may contribute to the increased ammonia level by its inhibition of carbonic anhydrase and cerebral glutamine synthetase, thereby facilitating VPA/TPM hyperammonemic encephalopathy. Recovery occurred after withdrawal of VPA or TPM.

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Year:  2000        PMID： 10636156     DOI： 10.1212/wnl.54.1.230

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  37 in total

Review 1.  New antiepileptic drugs.

Authors:  C W Bazil
Journal:  Curr Neurol Neurosci Rep       Date:  2001-07       Impact factor: 5.081

Review 2.  Drug-induced cerebellar ataxia: a systematic review.

Authors:  J van Gaalen; F G Kerstens; R P P W M Maas; L Härmark; B P C van de Warrenburg
Journal:  CNS Drugs       Date:  2014-12       Impact factor: 5.749

3.  Valproate-induced hyperammonemic encephalopathy: a case report.

Authors:  Vikas Mangewala; Sajjad Sarwar; Ryan Rosenberger; Theodor Rais; Michele Knox
Journal:  Innov Clin Neurosci       Date:  2013-05

4.  Encephalopathy induced by combination therapy with valproic Acid and topiramate: challenging the utility of serum ammonia measurement.

Authors:  Osric Sin; Josh Batterink
Journal:  Can J Hosp Pharm       Date:  2015 Jan-Feb

5.  Topiramate as an adjunctive treatment in patients with refractory status epilepticus: an observational cohort study.

Authors:  Annalena Hottinger; Raoul Sutter; Stephan Marsch; Stephan Rüegg
Journal:  CNS Drugs       Date:  2012-09-01       Impact factor: 5.749

6.  Valproic Acid and topiramate induced hyperammonemic encephalopathy in a patient with normal serum carnitine.

Authors:  Martha G Blackford; Stephanie T Do; Thomas C Enlow; Michael D Reed
Journal:  J Pediatr Pharmacol Ther       Date:  2013-04

7.  Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity.

Authors:  Shobhana Sivathanu; Sowmya Sampath; Madhubala Veerasamy; Satheeshkumar Sunderkumar
Journal:  BMJ Case Rep       Date:  2014-04-15

8.  Valproic Acid-Induced Hyperammonemic Encephalopathy as a Cause of Neurologic Deterioration after Unruptured Aneurysm Surgery.

Authors:  Sangkook Lee; Jinhwan Cheong; Choonghyun Kim; Jae Min Kim
Journal:  J Korean Neurosurg Soc       Date:  2015-08-28

9.  Topiramate in the treatment of partial and generalized epilepsy.

Authors:  Edward Faught
Journal:  Neuropsychiatr Dis Treat       Date:  2007-12       Impact factor: 2.570

10.  Valproic Acid-induced hyperammonemia in the elderly: a review of the literature.

Authors:  Vikrant Mittal; Sunanda Muralee; Rajesh R Tampi
Journal:  Case Rep Med       Date:  2009-08-19
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