Literature DB >> 10634790

Severely reduced female fertility in CD9-deficient mice.

F Le Naour1, E Rubinstein, C Jasmin, M Prenant, C Boucheix.   

Abstract

CD9 is a widely expressed cell surface molecule that belongs to the tetraspanin superfamily of proteins. The tetraspanins CD9, KAI-1/CD82, and CD63 are involved in metastasis suppression, an effect that may be related to their association with beta1 integrins. Knockout mice lacking CD9 were created to evaluate the physiological importance of CD9. CD9-/- females displayed a severe reduction of fertility. Oocytes were ovulated but were not successfully fertilized because sperm did not fuse with the oocytes from CD9-/- females. Thus, CD9 appears to be essential for sperm-egg fusion, a process involving the CD9-associated integrin alpha6beta1.

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Year:  2000        PMID： 10634790     DOI： 10.1126/science.287.5451.319

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  177 in total

1.  Specific interactions among transmembrane 4 superfamily (TM4SF) proteins and phosphoinositide 4-kinase.

Authors:  R L Yauch; M E Hemler
Journal:  Biochem J       Date:  2000-11-01       Impact factor: 3.857

2.  Palmitoylation of tetraspanin proteins: modulation of CD151 lateral interactions, subcellular distribution, and integrin-dependent cell morphology.

Authors:  Xiuwei Yang; Christoph Claas; Stine-Kathrein Kraeft; Lan Bo Chen; Zemin Wang; Jordan A Kreidberg; Martin E Hemler
Journal:  Mol Biol Cell       Date:  2002-03       Impact factor: 4.138

3.  EWI-2 is a new component of the tetraspanin web in hepatocytes and lymphoid cells.

Authors:  Stéphanie Charrin; François Le Naour; Valérie Labas; Martine Billard; Jean-Pierre Le Caer; Jean-François Emile; Marie-Anne Petit; Claude Boucheix; Eric Rubinstein
Journal:  Biochem J       Date:  2003-07-15       Impact factor: 3.857

4.  Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion.

Authors:  Diego A Ellerman; Cam Ha; Paul Primakoff; Diana G Myles; Gabriela S Dveksler
Journal:  Mol Biol Cell       Date:  2003-10-03       Impact factor: 4.138

5.  Expression profiling of mammalian male meiosis and gametogenesis identifies novel candidate genes for roles in the regulation of fertility.

Authors:  Ulrich Schlecht; Philippe Demougin; Reinhold Koch; Leandro Hermida; Christa Wiederkehr; Patrick Descombes; Charles Pineau; Bernard Jégou; Michael Primig
Journal:  Mol Biol Cell       Date:  2004-01-12       Impact factor: 4.138

6.  Characterization of mice lacking the tetraspanin superfamily member CD151.

Authors:  Mark D Wright; Sean M Geary; Stephen Fitter; Gregory W Moseley; Lai-Man Lau; Kuo-Ching Sheng; Vasso Apostolopoulos; Edouard G Stanley; Denise E Jackson; Leonie K Ashman
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

7.  A net-like structure with pores is observed during cell fusion induced by the receptor FGFRL1.

Authors:  Beat Trueb; Florian Steinberg
Journal:  Commun Integr Biol       Date:  2011-05

8.  Distinct MHC class II molecules are associated on the dendritic cell surface in cholesterol-dependent membrane microdomains.

Authors:  Sanjay Khandelwal; Paul A Roche
Journal:  J Biol Chem       Date:  2010-09-10       Impact factor: 5.157

Review 9.  The stem cell identity of testicular cancer.

Authors:  Amander T Clark
Journal:  Stem Cell Rev       Date:  2007-01       Impact factor: 5.739

10.  Endothelial adhesion receptors are recruited to adherent leukocytes by inclusion in preformed tetraspanin nanoplatforms.

Authors:  Olga Barreiro; Moreno Zamai; María Yáñez-Mó; Emilio Tejera; Pedro López-Romero; Peter N Monk; Enrico Gratton; Valeria R Caiolfa; Francisco Sánchez-Madrid
Journal:  J Cell Biol       Date:  2008-10-27       Impact factor: 10.539
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