Literature DB >> 10634650

Acute promyelocytic leukemia with del(6)(p23).

K Nakase1, Y Wakita, K Minamikawa, T Yamaguchi, H Shiku.   

Abstract

We report a unique case of de novo acute promyelocytic leukemia (APL) with cryptic 15;17 rearrangements. Cytogenetically, structural rearrangements of the 6p23 region has been reported mainly in secondary leukemia. This patient had a karyotype of 46, XY, del(6)(p23) and no additional chromosomal abnormalities. Molecular analyses revealed the presence of PML-RAR alpha fusion genes. Deletion of the 6p23 region is extremely rare in APL.

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Year:  2000        PMID： 10634650     DOI： 10.1016/s0145-2126(99)00139-3

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  3 in total

1.  Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.

Authors:  Colleen L Doçi; Tanmayi P Mankame; Alexander Langerman; Kelly R Ostler; Rajani Kanteti; Timothy Best; Kenan Onel; Lucy A Godley; Ravi Salgia; Mark W Lingen
Journal:  Int J Gynecol Pathol       Date:  2012-01       Impact factor: 2.762

2.  Identification and characterization of the human NOL7 gene promoter.

Authors:  Tanmayi P Mankame; Guolin Zhou; Mark W Lingen
Journal:  Gene       Date:  2010-03-03       Impact factor: 3.688

3.  Identification and functional analysis of NOL7 nuclear and nucleolar localization signals.

Authors:  Guolin Zhou; Colleen L Doçi; Mark W Lingen
Journal:  BMC Cell Biol       Date:  2010-09-27       Impact factor: 4.241
  3 in total

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