OBJECTIVE: To evaluate the ability of collagen film, collagen gel, sodium hyaluronate/carboxymethylcellulose film, and fibrin glue to prevent adhesion formation. DESIGN: Randomized trial using a rat model of a standardized abdominal wound and cecal wound. SETTING: University research laboratory. ANIMAL(S): Sprague-Dawley female rats. INTERVENTION(S): Resorbable barriers or no barrier (controls) were placed between an abdominal wall wound (1 cm x 2 cm) and a similarly sized cecal wound. MAIN OUTCOME MEASURE(S): Adhesion formation between wounds was assessed and quantitated 7 days after surgery. RESULT(S): Without treatment, 34 of 35 untreated rats (97%) developed adhesions. Treatment with collagen gel (3 of 33 rats), collagen film (3 of 10 rats), or sodium hyaluronate/carboxymethylcellulose film (2 of 10 rats) significantly reduced the incidence of adhesion formation. Treatment with fibrin sealant resulted in 9 of 10 animals having adherent wounds 7 days after surgery. CONCLUSION(S): Resorbable barriers of collagen gel, collagen films and sodium hyaluronate/carboxymethylcellulose film were effective in significantly reducing adhesion formation. Fibrin sealant at 7 days had an incidence of adhesion formation similar to that in untreated control animals.
OBJECTIVE: To evaluate the ability of collagen film, collagen gel, sodium hyaluronate/carboxymethylcellulose film, and fibrin glue to prevent adhesion formation. DESIGN: Randomized trial using a rat model of a standardized abdominal wound and cecal wound. SETTING: University research laboratory. ANIMAL(S): Sprague-Dawley female rats. INTERVENTION(S): Resorbable barriers or no barrier (controls) were placed between an abdominal wall wound (1 cm x 2 cm) and a similarly sized cecal wound. MAIN OUTCOME MEASURE(S): Adhesion formation between wounds was assessed and quantitated 7 days after surgery. RESULT(S): Without treatment, 34 of 35 untreated rats (97%) developed adhesions. Treatment with collagen gel (3 of 33 rats), collagen film (3 of 10 rats), or sodium hyaluronate/carboxymethylcellulose film (2 of 10 rats) significantly reduced the incidence of adhesion formation. Treatment with fibrin sealant resulted in 9 of 10 animals having adherent wounds 7 days after surgery. CONCLUSION(S): Resorbable barriers of collagen gel, collagen films and sodium hyaluronate/carboxymethylcellulose film were effective in significantly reducing adhesion formation. Fibrin sealant at 7 days had an incidence of adhesion formation similar to that in untreated control animals.
Authors: J G Balique; S Benchetrit; J L Bouillot; J B Flament; C Gouillat; P Jarsaillon; M Lepère; G Mantion; J P Arnaud; E Magne; F Brunetti Journal: Hernia Date: 2004-12-02 Impact factor: 4.739
Authors: Martijne van 't Riet; Peggy J de Vos van Steenwijk; Fred Bonthuis; Richard L Marquet; Ewout W Steyerberg; Johannes Jeekel; H Jaap Bonjer Journal: Ann Surg Date: 2003-01 Impact factor: 12.969