Literature DB >> 10631330

The U.S. National Research Council's views of the radiation hazards in space.

R B Setlow1.   

Abstract

The author was the Chairman of a Task Group on the Biological Effects of Space Radiation formed as a result of discussions between NASA and the U.S. National Research Council's Committee on Space Biology and Medicine - a committee under the U.S. National Research Council's Space Studies Board. The Task Group was asked to review current knowledge on the effects of long-term exposure to radiation in space and to consider NASA radiation shielding requirements for orbital and interplanetary spacecraft. The group was charged with assessing the adequacy of NASA planning for the protection of humans from radiation in space and with making recommendations regarding needed research and/or new shielding requirements. This manuscript is a summary of the findings and recommendations of the Task Group. Beyond the protection of the Earth's atmosphere and its magnetosphere, the exposure to ionizing radiations far exceeds that on Earth. Of all the risks astronauts may face, this one is probably the most straightforward to control - by providing adequate shielding. However, because shielding adds weight, cost and complexity to space vehicles, it is important for designers to have a good quantitative understanding of the true risk and its degree of uncertainty so as not to under- or overshield spacecrafts. The extrapolations from our knowledge of ionizing radiation effects of low linear energy transfer (LET) to the risks from high-atomic-number high-energy energetic (HZE) cosmic rays are very uncertain because the necessary experiments on the effects of such particles have not been carried out and the extrapolation from low-LET to very high-LET has great uncertainties. These uncertainties were enumerated by the Task Group, and the types of experiments needed to minimize the uncertainties were described. The report found that, because of the small amounts of available time for biological research at HZE accelerators, it would take more than a decade of effort to obtain the answers to a narrow set of key questions that would facilitate reduction in risks and identification of the types of shielding needed.

Entities:  

Keywords:  Non-programmatic

Mesh:

Year:  1999        PMID: 10631330     DOI: 10.1016/s0027-5107(99)00127-x

Source DB:  PubMed          Journal:  Mutat Res        ISSN: 0027-5107            Impact factor:   2.433


  7 in total

1.  The hazards of space travel.

Authors:  Richard B Setlow
Journal:  EMBO Rep       Date:  2003-11       Impact factor: 8.807

2.  Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain.

Authors:  E C Ford; P Achanta; D Purger; M Armour; J Reyes; J Fong; L Kleinberg; K Redmond; J Wong; M H Jang; H Jun; H-J Song; A Quinones-Hinojosa
Journal:  Radiat Res       Date:  2011-03-30       Impact factor: 2.841

3.  Germ cell mutagenesis in medaka fish after exposures to high-energy cosmic ray nuclei: A human model.

Authors:  Atsuko Shimada; Akihiro Shima; Kumie Nojima; Yo Seino; Richard B Setlow
Journal:  Proc Natl Acad Sci U S A       Date:  2005-04-13       Impact factor: 11.205

4.  Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine.

Authors:  Kamal Datta; Shubhankar Suman; Bhaskar V S Kallakury; Albert J Fornace
Journal:  PLoS One       Date:  2012-08-24       Impact factor: 3.240

5.  Neurocytotoxic effects of iron-ions on the developing brain measured in vivo using medaka (Oryzias latipes), a vertebrate model.

Authors:  Takako Yasuda; Shoji Oda; Hiroshi Yasuda; Yusuke Hibi; Kazunori Anzai; Hiroshi Mitani
Journal:  Int J Radiat Biol       Date:  2011-07-19       Impact factor: 2.694

Review 6.  Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway.

Authors:  Kamal Datta; Shubhankar Suman; Santosh Kumar; Albert J Fornace
Journal:  J Cancer       Date:  2016-01-01       Impact factor: 4.207

7.  Simulated Microgravity Altered the Metabolism of Loureirin B and the Expression of Major Cytochrome P450 in Liver of Rats.

Authors:  Bo Chen; Jingjing Guo; Shibo Wang; Liting Kang; Yulin Deng; Yujuan Li
Journal:  Front Pharmacol       Date:  2018-10-12       Impact factor: 5.810

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.