Literature DB >> 10630631

An Mn2+-stimulated neutral-sphingomyelinase in seminiferous tubules of immature Wistar rats.

P E Raimann1, I C Custodio de Souza, E A Bernard, F C Guma.   

Abstract

Mammalian sphingomyelinases have been implicated in many important physiological and pathophysiological processes. The seminiferous tubules of immature (19 day-old) Wistar rats have at least three types of sphingomyelinases, a lysosomal one and two microsomal ones. One of the microsomal sphingomyelinases is active at pH 6.5 and is stimulated by Mn2+ > Co2+ > Mg2+, and the other is active at pH 7.4 and is stimulated by Mn2+ > Mg2+ and inhibited by Co2+. The two microsomal enzymes are only slightly inhibited by EDTA and at pH 7.4 the stimulatory effects of Mn2+ and Mg2+ are additive. These data characterize the existence of two different membrane-bound sphingomyelinases in the seminiferous tubules of the rat.

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Year:  1999        PMID： 10630631     DOI： 10.1023/a:1007046024246

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  20 in total

1.  Neutral and acid sphingomyelinases: somatotopographical distribution in human brain and distribution in rat organs. A possible relationship with the dopamine system.

Authors:  M W Spence; J K Burgess; E R Sperker
Journal:  Brain Res       Date:  1979-06-08       Impact factor: 3.252

2.  Enzymatic hydrolysis of sphingolipids. II. Hydrolysis of sphingomyelin by an enzyme from rat brain.

Authors:  Y Barnholz; A Roitman; S Gatt
Journal:  J Biol Chem       Date:  1966-08-25       Impact factor: 5.157

3.  Influence of the biomatrix on the response of Sertoli cells to FSH.

Authors:  A B Rocha; F C Guma; E A Casali; G S Scherer; M A Elena; E A Bernard
Journal:  Arch Physiol Biochem       Date:  1997-09       Impact factor: 4.076

4.  Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene.

Authors:  S L Schissel; E H Schuchman; K J Williams; I Tabas
Journal:  J Biol Chem       Date:  1996-08-02       Impact factor: 5.157

5.  Fas-induced apoptosis in rat thecal/interstitial cells signals through sphingomyelin-ceramide pathway.

Authors:  A Foghi; A Ravandi; K J Teerds; H Van Der Donk; A Kuksis; J Dorrington
Journal:  Endocrinology       Date:  1998-04       Impact factor: 4.736

6.  Neutral sphingomyelinase: localization in rat liver nuclei and involvement in regeneration/proliferation.

Authors:  A Alessenko; S Chatterjee
Journal:  Mol Cell Biochem       Date:  1995-02-23       Impact factor: 3.396

7.  Glycoprotein biosynthesis by testes of 40-day-old rats subjected to protein malnutrition.

Authors:  F C Guma; R Guaragna; N B Rosa; G G Moraes; J L Gamallo; M L Perry; E A Bernard
Journal:  Int J Androl       Date:  1990-10

8.  Fas regulates germ cell apoptosis in the human testis in vitro.

Authors:  V Pentikäinen; K Erkkilä; L Dunkel
Journal:  Am J Physiol       Date:  1999-02

9.  Novel molecular species of sphingomyelin containing 2-hydroxylated polyenoic very-long-chain fatty acids in mammalian testes and spermatozoa.

Authors:  B S Robinson; D W Johnson; A Poulos
Journal:  J Biol Chem       Date:  1992-01-25       Impact factor: 5.157

10.  Sphingomyelinases in human, bovine and porcine seminal plasma.

Authors:  T Vanha-Perttula
Journal:  FEBS Lett       Date:  1988-06-20       Impact factor: 4.124
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  2 in total

1.  Synthesis and transport of different sphingomyelin species in rat Sertoli cells.

Authors:  A L Ziulkoski; A R Zimmer; J S Zanettini; L C Trugo; F C Guma
Journal:  Mol Cell Biochem       Date:  2001-03       Impact factor: 3.396

2.  Identification and characterization of murine mitochondria-associated neutral sphingomyelinase (MA-nSMase), the mammalian sphingomyelin phosphodiesterase 5.

Authors:  Bill X Wu; Vinodh Rajagopalan; Patrick L Roddy; Christopher J Clarke; Yusuf A Hannun
Journal:  J Biol Chem       Date:  2010-04-08       Impact factor: 5.157
  2 in total

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