Literature DB >> 10629205

Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis.

N H Carbonetti1, A Romashko, T J Irish.   

Abstract

Overexpression of the RNA polymerase alpha subunit in Bordetella pertussis reduces expression of the virulence factor pertussis toxin. Here we show that this reduction is at the level of transcription, is reversed by overexpression of the transcriptional activator BvgA, and is dependent on the C-terminal domain of alpha.

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Year:  2000        PMID： 10629205      PMCID： PMC94308          DOI： 10.1128/JB.182.2.529-531.2000

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  10 in total

1.  Analysis of BvgA activation of the pertactin gene promoter in Bordetella pertussis.

Authors:  S M Kinnear; P E Boucher; S Stibitz; N H Carbonetti
Journal:  J Bacteriol       Date:  1999-09       Impact factor: 3.490

Review 2.  Role of the RNA polymerase alpha subunit in transcription activation.

Authors:  A Ishihama
Journal:  Mol Microbiol       Date:  1992-11       Impact factor: 3.501

3.  Nature of DNA binding and RNA polymerase interaction of the Bordetella pertussis BvgA transcriptional activator at the fha promoter.

Authors:  P E Boucher; K Murakami; A Ishihama; S Stibitz
Journal:  J Bacteriol       Date:  1997-03       Impact factor: 3.490

4.  Intracellular delivery of a cytolytic T-lymphocyte epitope peptide by pertussis toxin to major histocompatibility complex class I without involvement of the cytosolic class I antigen processing pathway.

Authors:  N H Carbonetti; T J Irish; C H Chen; C B O'Connell; G A Hadley; U McNamara; R G Tuskan; G K Lewis
Journal:  Infect Immun       Date:  1999-02       Impact factor: 3.441

5.  Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins.

Authors:  B Aricó; J F Miller; C Roy; S Stibitz; D Monack; S Falkow; R Gross; R Rappuoli
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

6.  A simple chemically defined medium for the production of phase I Bordetella pertussis.

Authors:  D W Stainer; M J Scholte
Journal:  J Gen Microbiol       Date:  1970-10

7.  Genetic analysis of pertussis toxin promoter activation in Bordetella pertussis.

Authors:  R R Marques; N H Carbonetti
Journal:  Mol Microbiol       Date:  1997-06       Impact factor: 3.501

8.  Characterization of the gene encoding superoxide dismutase of Bordetella pertussis and construction of a SOD-deficient mutant.

Authors:  D DeShazer; J D Bannan; M J Moran; R L Friedman
Journal:  Gene       Date:  1994-05-03       Impact factor: 3.688

9.  Phosphorylated BvgA is sufficient for transcriptional activation of virulence-regulated genes in Bordetella pertussis.

Authors:  P Steffen; S Goyard; A Ullmann
Journal:  EMBO J       Date:  1996-01-02       Impact factor: 11.598

10.  Effect of mutations causing overexpression of RNA polymerase alpha subunit on regulation of virulence factors in Bordetella pertussis.

Authors:  N H Carbonetti; T M Fuchs; A A Patamawenu; T J Irish; H Deppisch; R Gross
Journal:  J Bacteriol       Date:  1994-12       Impact factor: 3.490
  10 in total
  4 in total

1.  Bordetella pertussis autoregulates pertussis toxin production through the metabolism of cysteine.

Authors:  J A Bogdan; J Nazario-Larrieu; J Sarwar; P Alexander; M S Blake
Journal:  Infect Immun       Date:  2001-11       Impact factor: 3.441

2.  Reconstitution of acetosyringone-mediated Agrobacterium tumefaciens virulence gene expression in the heterologous host Escherichia coli.

Authors:  S M Lohrke; H Yang; S Jin
Journal:  J Bacteriol       Date:  2001-06       Impact factor: 3.490

3.  Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III in Streptococcus pyogenes.

Authors:  Anaïs Le Rhun; Anne-Laure Lécrivain; Johan Reimegård; Estelle Proux-Wéra; Laura Broglia; Cristina Della Beffa; Emmanuelle Charpentier
Journal:  Nucleic Acids Res       Date:  2017-03-17       Impact factor: 16.971

4.  A Mutation Upstream of the rplN-rpsD Ribosomal Operon Downregulates Bordetella pertussis Virulence Factor Production without Compromising Bacterial Survival within Human Macrophages.

Authors:  Jakub Novák; David Jurnečka; Irena Linhartová; Jana Holubová; Ondřej Staněk; Daniel Štipl; Ana Dienstbier; Branislav Večerek; Nayara Azevedo; Jan Provazník; Vladimír Beneš; Peter Šebo
Journal:  mSystems       Date:  2020-12-08       Impact factor: 6.496
  4 in total

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