Literature DB >> 10629019

Detrimental effect of the combination of R164S with G238S in TEM-1 beta-lactamase on the extended-spectrum activity conferred by each single mutation.

P Giakkoupi1, E Tzelepi, P T Tassios, N J Legakis, L S Tzouvelekis.   

Abstract

The non-naturally occurring TEM-1 beta-lactamase mutant R164S:G238S, as well as the R164S (TEM-12) and G238S (TEM-19) beta-lactamases, were constructed and expressed in Escherichia coli under isogenic conditions. Comparison of susceptibilities to beta-lactam antibiotics and substrate profiles showed that the combination of R164S with G238S drastically reduced the extended-spectrum activity of the respective single mutants.

Entities:  

Mesh：

Substances：

Year:  2000        PMID： 10629019     DOI： 10.1093/jac/45.1.101

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  12 in total

1.  Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.

Authors:  Eynat Dellus-Gur; Mikael Elias; Emilia Caselli; Fabio Prati; Merijn L M Salverda; J Arjan G M de Visser; James S Fraser; Dan S Tawfik
Journal:  J Mol Biol       Date:  2015-05-22       Impact factor: 5.469

2.  Beyond Piperacillin-Tazobactam: Cefepime and AAI101 as a Potent β-Lactam-β-Lactamase Inhibitor Combination.

Authors:  Krisztina M Papp-Wallace; Christopher R Bethel; Jocelyne Caillon; Melissa D Barnes; Gilles Potel; Saralee Bajaksouzian; Joseph D Rutter; Amokrane Reghal; Stuart Shapiro; Magdalena A Taracila; Michael R Jacobs; Robert A Bonomo; Cédric Jacqueline
Journal:  Antimicrob Agents Chemother       Date:  2019-04-25       Impact factor: 5.191

3.  Antagonism between substitutions in β-lactamase explains a path not taken in the evolution of bacterial drug resistance.

Authors:  Cameron A Brown; Liya Hu; Zhizeng Sun; Meha P Patel; Sukrit Singh; Justin R Porter; Banumathi Sankaran; B V Venkataram Prasad; Gregory R Bowman; Timothy Palzkill
Journal:  J Biol Chem       Date:  2020-04-16       Impact factor: 5.157

4.  Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.

Authors:  Jared M Sampson; Wei Ke; Christopher R Bethel; S R R Pagadala; Michael D Nottingham; Robert A Bonomo; John D Buynak; Focco van den Akker
Journal:  Antimicrob Agents Chemother       Date:  2011-02-28       Impact factor: 5.191

5.  Activities of ceftazidime, ceftaroline, and aztreonam alone and combined with avibactam against isogenic Escherichia coli strains expressing selected single β-lactamases.

Authors:  Krisztina M Papp-Wallace; Saralee Bajaksouzian; Ayman M Abdelhamed; Altreisha N Foster; Marisa L Winkler; Julian A Gatta; Wright W Nichols; Raymond Testa; Robert A Bonomo; Michael R Jacobs
Journal:  Diagn Microbiol Infect Dis       Date:  2015-02-14       Impact factor: 2.803

6.  Molecular characterization of extended-spectrum beta-lactamases produced by clinical isolates of Klebsiella pneumoniae and Escherichia coli from a Korean nationwide survey.

Authors:  Seok Hoon Jeong; Il Kwon Bae; Jung Hun Lee; Seung Ghyu Sohn; Geun Ho Kang; Ghil Ja Jeon; Young Ho Kim; Byeong Chul Jeong; Sang Hee Lee
Journal:  J Clin Microbiol       Date:  2004-07       Impact factor: 5.948

7.  Choice of β-Lactam Resistance Pathway Depends Critically on Initial Antibiotic Concentration.

Authors:  Philip Ruelens; J Arjan G M de Visser
Journal:  Antimicrob Agents Chemother       Date:  2021-07-16       Impact factor: 5.191

8.  Initial mutations direct alternative pathways of protein evolution.

Authors:  Merijn L M Salverda; Eynat Dellus; Florien A Gorter; Alfons J M Debets; John van der Oost; Rolf F Hoekstra; Dan S Tawfik; J Arjan G M de Visser
Journal:  PLoS Genet       Date:  2011-03-03       Impact factor: 5.917

9.  Network models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectories.

Authors:  Violeta Beleva Guthrie; Jennifer Allen; Manel Camps; Rachel Karchin
Journal:  PLoS Comput Biol       Date:  2011-09-22       Impact factor: 4.475

10.  Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.

Authors:  Martijn F Schenk; Ivan G Szendro; Merijn L M Salverda; Joachim Krug; J Arjan G M de Visser
Journal:  Mol Biol Evol       Date:  2013-05-15       Impact factor: 16.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.