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Literature DB >> 10628836

PSMA mimotope isolated from phage displayed peptide library can induce PSMA specific immune response.

Z Y Zhu¹, C P Zhong, W F Xu, G M Lin, G Q Ye, Y Y Ji, B Sun, M Yeh.

Abstract

Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein expressed predominantly in prostate secretory acinar epithelium and prostate cancer cells as well as in several extraprostatic tissues. Mouse monoclonal antibody 4G5 specific to the extracellular domain of PSMA was used to screen two phage displayed peptide libraries (9aa linear and 9aa cys library). Three 4G5-reactive phagotopes were identified. Sequence analysis of isolated clones demonstrated that the interaction motif "VDPA/SK" has high homology to 719-725aa on PSMA. Immunohistochemical staining of the prostate cancer sample with the PSMA-mimic phagotope (mimotope) immunized serum antibodies demonstrate that the mimotope isolated from the phage displayed peptide libraries can induce PSMA specific immune response in vivo.

Entities: Chemical Disease Gene Species

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Year: 1999 PMID： 10628836 DOI： 10.1038/sj.cr.7290026

Source DB: PubMed Journal: Cell Res ISSN： 1001-0602 Impact factor: 25.617

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Cited

7 in total

1. Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stages.

Authors: Andrew Gray; Maria de la Luz Garcia-Hernandez; Myrna van West; Shreya Kanodia; Bolyn Hubby; W Martin Kast
Journal: Vaccine Date: 2009-12-30 Impact factor: 3.641

Review 2. Phage display in molecular imaging and diagnosis of cancer.

Authors: Susan L Deutscher
Journal: Chem Rev Date: 2010-05-12 Impact factor: 60.622

3. PSMA-positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state.

Authors: Ryuta Watanabe; Masashi Maekawa; Takeshi Kiyoi; Mie Kurata; Noriyoshi Miura; Tadahiko Kikugawa; Shigeki Higashiyama; Takashi Saika
Journal: Prostate Date: 2021-09-13 Impact factor: 4.012

7. A Novel Prostate-Specific Membrane-Antigen (PSMA) Targeted Micelle-Encapsulating Wogonin Inhibits Prostate Cancer Cell Proliferation via Inducing Intrinsic Apoptotic Pathway.

Authors: Hailong Zhang; Xiaogang Liu; Fengbo Wu; Feifei Qin; Ping Feng; Ting Xu; Xiang Li; Li Yang
Journal: Int J Mol Sci Date: 2016-05-17 Impact factor: 5.923

7 in total

PSMA mimotope isolated from phage displayed peptide library can induce PSMA specific immune response.

1. Prostate cancer immunotherapy yields superior long-term survival in TRAMP mice when administered at an early stage of carcinogenesis prior to the establishment of tumor-associated immunosuppression at later stages.

Review 2. Phage display in molecular imaging and diagnosis of cancer.

3. PSMA-positive membranes secreted from prostate cancer cells have potency to transform vascular endothelial cells into an angiogenic state.

Review 4. DNA vaccination: using the patient's immune system to overcome cancer.

Review 5. Mimotope vaccines: epitope mimics induce anti-cancer antibodies.

6. Evaluation of phage display discovered peptides as ligands for prostate-specific membrane antigen (PSMA).

7. A Novel Prostate-Specific Membrane-Antigen (PSMA) Targeted Micelle-Encapsulating Wogonin Inhibits Prostate Cancer Cell Proliferation via Inducing Intrinsic Apoptotic Pathway.