M O Simovic1, M J Bonham, F M Abu-Zidan, J A Windsor. 1. Pancreatitis Research Group, Department of Surgery, Faculty of Medicine and Health Science, University of Auckland, New Zealand.
Abstract
OBJECTIVE: To test the hypothesis that elevated interleukin (IL)-10 plasma concentration relative to IL-6 and IL-8 in patients with acute pancreatitis is associated with improved clinical outcome. DESIGN: Case series. SETTING: University hospital surgical and intensive care unit. PATIENTS: Patients with mild (n = 18) and severe (n = 14) acute pancreatitis were recruited within 12 hrs of admission and studied for 5 days. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The plasma concentration of IL-10 was significantly elevated in patients with severe pancreatitis during the 5 days and especially so in those who died compared with survivors on day 5 (p <.03). The ratio of IL-10/IL-6 was decreased in patients with severe pancreatitis on day 5 (p < .01). There was a significant decrease in the ratio of IL-10/IL-8, but not of IL-10/IL-6, during the first 5 days (p < .014). CONCLUSIONS: The findings are consistent with the hypothesis that an increase in plasma IL-10 relative to IL-6 or IL-8 is associated with improved clinical outcome.
OBJECTIVE: To test the hypothesis that elevated interleukin (IL)-10 plasma concentration relative to IL-6 and IL-8 in patients with acute pancreatitis is associated with improved clinical outcome. DESIGN: Case series. SETTING: University hospital surgical and intensive care unit. PATIENTS: Patients with mild (n = 18) and severe (n = 14) acute pancreatitis were recruited within 12 hrs of admission and studied for 5 days. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The plasma concentration of IL-10 was significantly elevated in patients with severe pancreatitis during the 5 days and especially so in those who died compared with survivors on day 5 (p <.03). The ratio of IL-10/IL-6 was decreased in patients with severe pancreatitis on day 5 (p < .01). There was a significant decrease in the ratio of IL-10/IL-8, but not of IL-10/IL-6, during the first 5 days (p < .014). CONCLUSIONS: The findings are consistent with the hypothesis that an increase in plasma IL-10 relative to IL-6 or IL-8 is associated with improved clinical outcome.
Authors: Raquel Laveda; Juan Martinez; Carlos Munoz; Juan-Carlos Penalva; Jesus Saez; German Belda; Salvador Navarro; Faust Feu; Anton Mas; Jose-Ma Palazon; Jose Sanchez-Paya; Jose Such; Miguel Perez-Mateo Journal: World J Gastroenterol Date: 2005-09-14 Impact factor: 5.742
Authors: Fernando A Rivera-Chavez; Herbert Wheeler; Guy Lindberg; Robert S Munford; Grant E O'Keefe Journal: Ann Surg Date: 2003-03 Impact factor: 12.969