Literature DB >> 10627525

The explosive human immunodeficiency virus type 1 epidemic among injecting drug users of Kathmandu, Nepal, is caused by a subtype C virus of restricted genetic diversity.

R B Oelrichs1, I L Shrestha, D A Anderson, N J Deacon.   

Abstract

An explosive epidemic of human immunodeficiency virus type 1 (HIV-1) has been documented among the injecting drug user population of Kathmandu, Nepal, whose seropositivity rate has risen from 0 to 40% between 1995 and 1997. By using Catrimox to preserve whole-blood RNA at ambient temperature for transportation, HIV-1 envelope V3-V4 sequences were obtained from 36 patients in this group. Analysis of the sequences indicated a homogenous epidemic of subtype C virus, with at least two independent introductions of the virus into the population. Viral diversity was restricted within two transmission subclusters, with the majority of variation occurring in V4. Calculation of the synonymous-to-nonsynonymous mutation ratio (Ks:Ka) across this region showed that significant evolutionary pressure had been experienced during the rapid horizontal spread of the virus in this population, most strongly directed to the region between V3 and V4.

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Year:  2000        PMID： 10627525      PMCID： PMC111449          DOI： 10.1128/jvi.74.3.1149-1157.2000

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  30 in total

1.  Envelope glycoprotein 120 sequences of primary HIV type 1 isolates from Pune and New Delhi, India.

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Journal:  AIDS Res Hum Retroviruses       Date:  1996-08-10       Impact factor: 2.205

2.  Molecular epidemiology of HIV transmission in a dental practice.

Authors:  C Y Ou; C A Ciesielski; G Myers; C I Bandea; C C Luo; B T Korber; J I Mullins; G Schochetman; R L Berkelman; A N Economou
Journal:  Science       Date:  1992-05-22       Impact factor: 47.728

3.  HIV-1 strains from India are highly divergent from prototypic African and US/European strains, but are linked to a South African isolate.

Authors:  U Dietrich; M Grez; H von Briesen; B Panhans; M Geissendörfer; H Kühnel; J Maniar; G Mahambre; W B Becker; M L Becker
Journal:  AIDS       Date:  1993-01       Impact factor: 4.177

4.  Unbiased estimation of the rates of synonymous and nonsynonymous substitution.

Authors:  W H Li
Journal:  J Mol Evol       Date:  1993-01       Impact factor: 2.395

5.  Declining risk for HIV among injecting drug users in Kathmandu, Nepal: the impact of a harm-reduction programme.

Authors:  A Peak; S Rana; S H Maharjan; D Jolley; N Crofts
Journal:  AIDS       Date:  1995-09       Impact factor: 4.177

6.  Intraspecific phylogenetics: support for dental transmission of human immunodeficiency virus.

Authors:  K A Crandall
Journal:  J Virol       Date:  1995-04       Impact factor: 5.103

7.  Analysis of sequence diversity in hypervariable regions of the external glycoprotein of human immunodeficiency virus type 1.

Authors:  P Simmonds; P Balfe; C A Ludlam; J O Bishop; A J Brown
Journal:  J Virol       Date:  1990-12       Impact factor: 5.103

8.  Direct detection of hepatitis C virus (HCV) RNA from whole blood, and comparison with HCV RNA in plasma and peripheral blood mononuclear cells.

Authors:  W N Schmidt; D Klinzman; D R LaBrecque; D E Macfarlane; J T Stapleton
Journal:  J Med Virol       Date:  1995-10       Impact factor: 2.327

9.  Genetic diversity of the envelope glycoprotein from human immunodeficiency virus type 1 isolates of African origin.

Authors:  J Louwagie; W Janssens; J Mascola; L Heyndrickx; P Hegerich; G van der Groen; F E McCutchan; D S Burke
Journal:  J Virol       Date:  1995-01       Impact factor: 5.103

10.  Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients.

Authors:  N J Deacon; A Tsykin; A Solomon; K Smith; M Ludford-Menting; D J Hooker; D A McPhee; A L Greenway; A Ellett; C Chatfield; V A Lawson; S Crowe; A Maerz; S Sonza; J Learmont; J S Sullivan; A Cunningham; D Dwyer; D Dowton; J Mills
Journal:  Science       Date:  1995-11-10       Impact factor: 47.728
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  12 in total

1.  HIV-1 circulating recombinant form in Nepal.

Authors:  Aniqa Shahid; Sameer M Dixit; V L Gurbacharya; Dibesh Karmacharya; Syed Ali
Journal:  J Virol       Date:  2011-06-15       Impact factor: 5.103

2.  Prevalence and risk factors of chlamydia and gonorrhea among rural Nepali women.

Authors:  P Christian; S K Khatry; S C LeClerq; A A Roess; L Wu; J D Yuenger; J M Zenilman
Journal:  Sex Transm Infect       Date:  2005-06       Impact factor: 3.519

3.  T-helper-cell proliferative responses to whole-killed human immunodeficiency virus type 1 (HIV-1) and p24 antigens of different clades in HIV-1-infected subjects vaccinated with HIV-1 immunogen (Remune).

Authors:  R B Moss; W Giermakowska; M R Wallace; J Savary; F Jensen; D J Carlo
Journal:  Clin Diagn Lab Immunol       Date:  2000-09

4.  A recent outbreak of human immunodeficiency virus type 1 infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant.

Authors:  S Piyasirisilp; F E McCutchan; J K Carr; E Sanders-Buell; W Liu; J Chen; R Wagner; H Wolf; Y Shao; S Lai; C Beyrer; X F Yu
Journal:  J Virol       Date:  2000-12       Impact factor: 5.103

5.  Human immunodeficiency virus type 1 env sequences from Calcutta in eastern India: identification of features that distinguish subtype C sequences in India from other subtype C sequences.

Authors:  R Shankarappa; R Chatterjee; G H Learn; D Neogi; M Ding; P Roy; A Ghosh; L Kingsley; L Harrison; J I Mullins; P Gupta
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103

6.  Timing and reconstruction of the most recent common ancestor of the subtype C clade of human immunodeficiency virus type 1.

Authors:  Simon A A Travers; Jonathan P Clewley; Judith R Glynn; Paul E M Fine; Amelia C Crampin; Felix Sibande; Dominic Mulawa; James O McInerney; Grace P McCormack
Journal:  J Virol       Date:  2004-10       Impact factor: 5.103

Review 7.  Overview of HIV molecular epidemiology among people who inject drugs in Europe and Asia.

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Journal:  Infect Genet Evol       Date:  2016-06-07       Impact factor: 3.342

8.  Nef-mediated MHC class I down-regulation unmasks clonal differences in virus suppression by SIV-specific CD8(+) T cells independent of IFN-gamma and CD107a responses.

Authors:  Jacob T Minang; Matthew T Trivett; Lori V Coren; Eugene V Barsov; Michael Piatak; David E Ott; Claes Ohlen
Journal:  Virology       Date:  2009-06-24       Impact factor: 3.616

9.  HIV in Nepal: is the violent conflict fuelling the epidemic?

Authors:  Sonal Singh; Edward Mills; Steven Honeyman; Bal Krishna Suvedi; Nur Prasad Pant
Journal:  PLoS Med       Date:  2005-07-19       Impact factor: 11.069

10.  Evolution of subtype C HIV-1 Env in a slowly progressing Zambian infant.

Authors:  Hong Zhang; Federico Hoffmann; Jun He; Xiang He; Chipepo Kankasa; Ruth Ruprecht; John T West; Guillermo Orti; Charles Wood
Journal:  Retrovirology       Date:  2005-11-07       Impact factor: 4.602
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