| Literature DB >> 1062623 |
A Pelfrene, S S Mirvish, B Gold.
Abstract
Forty male MRC-W rats were treated chronically with 1-(2-hydroxyethyl)-1-nitrosourea in drinking water (total dose, 330 mg/rat). Fifteen rats (38%) developed osteogenic osteosarcomas or chondrosarcomas of the lower vertebrae. This was the first time that an orally administered organic compound induced a high incidence of these tumors.Entities:
Mesh：
Substances：
Year: 1976 PMID： 1062623 DOI： 10.1093/jnci/56.2.445
Source DB: PubMed Journal: J Natl Cancer Inst ISSN： 0027-8874 Impact factor: 13.506