| Literature DB >> 10626 |
J R Sporn, T K Harden, B B Wolfe, P B Molinoff.
Abstract
The intraventricular administration of 6-hydroxydopamine, a procedure which destroys noradrenergic nerve terminals in the central nervous system, caused an increase in the density of beta-adrenergic receptors in rat cerebral cortex, without affecting their affinity for isoproterenol. The results suggest that changes in the density of adrenergic receptors are involved in 6-hydroxydopamine-induced supersensitivity at central noradrenergic synapses.Entities:
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Year: 1976 PMID: 10626 DOI: 10.1126/science.10626
Source DB: PubMed Journal: Science ISSN: 0036-8075 Impact factor: 47.728