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Literature DB >> 10624871

Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line.

Y Yoon¹, Y O Kim, W K Jeon, H J Park, H J Sung.

Abstract

Apoptosis is a new therapeutic target of cancer research. Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE, a traditional oriental medical herb, was observed to induce apoptosis in HL60 human premyelocytic leukemia cell line. Tanshinone IIA induced DNA fragmentation into the multiples of 180 bp and increased the percentage of hypodiploid cells in flow cytometry after propidium iodide (PI) staining. Tanshinone IIA-induced apoptosis is accompanied by the specific proteolytic cleavage of poly(ADP-ribose) polymerase (PARP) and the activation of caspase-3, a major component in apoptotic cell death mechanism.

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Year: 1999 PMID： 10624871 DOI： 10.1016/s0378-8741(99)00059-8

Source DB: PubMed Journal: J Ethnopharmacol ISSN： 0378-8741 Impact factor: 4.360

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Cited

22 in total

1. A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine.

Authors: H Tian; L Ip; H Luo; D C Chang; K Q Luo
Journal: Br J Pharmacol Date: 2007-01-18 Impact factor: 8.739

10. Studies on polynuclear furoquinones. Part 1: synthesis of tri- and tetra-cyclic furoquinones simulating BCD/ABCD ring system of furoquinone diterpenoids.

Authors: Faruk Hasan Shaik; Gandhi Kumar Kar
Journal: Beilstein J Org Chem Date: 2009-09-29 Impact factor: 2.883

Tanshinone IIA isolated from Salvia miltiorrhiza BUNGE induced apoptosis in HL60 human premyelocytic leukemia cell line.

1. A high throughput drug screen based on fluorescence resonance energy transfer (FRET) for anticancer activity of compounds from herbal medicine.

2. Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function.

3. Increase of phosphatase and tensin homolog by silymarin to inhibit human pharynx squamous cancer.

4. Tanshinone IIA activates calcium-dependent apoptosis signaling pathway in human hepatoma cells.

5. The interplay between autophagy and apoptosis induced by tanshinone IIA in prostate cancer cells.

6. Growth inhibition and induction of apoptosis and differentiation of tanshinone IIA in human glioma cells.

7. Growth-inhibiting and apoptosis-inducing effects of Tanshinone II A on human gastric carcinoma cells.

8. Growth inhibition and apoptosis induction of tanshinone II-A on human hepatocellular carcinoma cells.

9. Inhibitory effects of tanshinone II-A on invasion and metastasis of human colon carcinoma cells.

10. Studies on polynuclear furoquinones. Part 1: synthesis of tri- and tetra-cyclic furoquinones simulating BCD/ABCD ring system of furoquinone diterpenoids.