BACKGROUND AND PURPOSE: The introduction of computed-tomography as an advanced planning tool for the irradiation of intracranial tumours led to a controversial discussions about the optimal target-volume for the primary and postoperative treatment of malignant gliomas. This study analyses the three-dimensional tumour regrowth pattern relative to the treated volume which included the macroscopic preoperative tumour and 2-cm safety margin. MATERIALS AND METHODS: Seventy-nine patients with histologically-confirmed Glioblastoma multiforma and documented recurrence who were irradiated in our department between 1990 and 1996 were reviewed. With the help of a computer program written for this purpose, the PTV of the CT-based treatment plan was reconstructed and its spatial outline compared with the reconstructed volume of the recurrent tumour in the control CT-study. RESULTS: In 33 out 34 patients for which the CT-study showing tumour-recurrence was available the recurrence was completely situated within the original 90%-isodose. Only one tumour surpassed the outside surface of the PTV but was predominantly situated within the original tumourbed and suggests a tumour-regrowth within the high dose volume. CONCLUSIONS: The above results show that target-volumes based on the preoperative size of the enhanced tumour mass well cover the site of recurrence in nearly all cases. The findings suggest dose escalation to a more restricted volume.
BACKGROUND AND PURPOSE: The introduction of computed-tomography as an advanced planning tool for the irradiation of intracranial tumours led to a controversial discussions about the optimal target-volume for the primary and postoperative treatment of malignant gliomas. This study analyses the three-dimensional tumour regrowth pattern relative to the treated volume which included the macroscopic preoperative tumour and 2-cm safety margin. MATERIALS AND METHODS: Seventy-nine patients with histologically-confirmed Glioblastoma multiforma and documented recurrence who were irradiated in our department between 1990 and 1996 were reviewed. With the help of a computer program written for this purpose, the PTV of the CT-based treatment plan was reconstructed and its spatial outline compared with the reconstructed volume of the recurrent tumour in the control CT-study. RESULTS: In 33 out 34 patients for which the CT-study showing tumour-recurrence was available the recurrence was completely situated within the original 90%-isodose. Only one tumour surpassed the outside surface of the PTV but was predominantly situated within the original tumourbed and suggests a tumour-regrowth within the high dose volume. CONCLUSIONS: The above results show that target-volumes based on the preoperative size of the enhanced tumour mass well cover the site of recurrence in nearly all cases. The findings suggest dose escalation to a more restricted volume.
Authors: P Farace; M G Giri; G Meliadò; D Amelio; L Widesott; G K Ricciardi; S Dall'Oglio; A Rizzotti; A Sbarbati; A Beltramello; S Maluta; M Amichetti Journal: Br J Radiol Date: 2010-11-02 Impact factor: 3.039
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Authors: N Andres Parra; Andrew A Maudsley; Rakesh K Gupta; Fazilat Ishkanian; Kris Huang; Gail R Walker; Kyle Padgett; Bhaswati Roy; Joseph Panoff; Arnold Markoe; Radka Stoyanova Journal: Int J Radiat Oncol Biol Phys Date: 2014-07-24 Impact factor: 7.038
Authors: Inge Compter; Jurgen Peerlings; Daniëlle B P Eekers; Alida A Postma; Dimo Ivanov; Christopher J Wiggins; Pieter Kubben; Benno Küsters; Pieter Wesseling; Linda Ackermans; Olaf E M G Schijns; Philippe Lambin; Aswin L Hoffmann Journal: MAGMA Date: 2016-03-30 Impact factor: 2.310
Authors: M D Piroth; M Pinkawa; R Holy; J Klotz; S Schaar; G Stoffels; N Galldiks; H H Coenen; H J Kaiser; K J Langen; M J Eble Journal: Strahlenther Onkol Date: 2012-02-22 Impact factor: 3.621
Authors: Jochen Tuettenberg; Rainer Grobholz; Marcel Seiz; Marc A Brockmann; Frank Lohr; Frederik Wenz; Peter Vajkoczy Journal: J Cancer Res Clin Oncol Date: 2009-03-10 Impact factor: 4.553