| Literature DB >> 10624823 |
J Ahveninen1, H Tiitinen, J Hirvonen, E Pekkonen, J Huttunen, S Kaakkola, I P Jääskeläinen.
Abstract
The influence of neocortical muscarinic transmission on auditory-evoked 40-Hz magnetic response was studied in 13 healthy subjects in a double-blind randomized cross-over design. Either a centrally (scopolamine hydrobromide, 0.3 mg, i.v.) or a peripherally (glycopyrrolate, 0.2 mg, i.v.) acting antagonist of muscarinic transmission was administered during two sessions of magnetoencephalographic recording of 40-Hz response elicited by monaural tones. Scopolamine significantly (P < 0.01) augmented the 40-Hz magnetic response over the hemispheres ipsi- and contralateral to the ear stimulated. This finding suggests muscarinic modulation of the auditory evoked transient 40-Hz response.Entities:
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Year: 1999 PMID： 10624823 DOI： 10.1016/s0304-3940(99)00854-x
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046