Literature DB >> 10623879

Multi-faceted regulation of gamma-glutamylcysteine synthetase.

S R Soltaninassab1, K R Sekhar, M J Meredith, M L Freeman.   

Abstract

Glutathione is an important antioxidant that is involved in numerous cellular activities. gamma-Glutamylcysteine synthetase (gammaGCS) is a key regulatory enzyme in the synthesis of glutathione. It is a heterodimeric zinc metalloprotein that belongs to a unique class of proteins that gain activity due to formation of a reversible disulfide bond. The two subunits of gammaGCS exhibit differential and coordinate transcription regulation. In addition, the subunits are regulated at the posttranscriptional and posttranslational levels. These various levels of regulation allow numerous stimuli to induce or inhibit activity. Copyright 2000 Wiley-Liss, Inc.

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Year:  2000        PMID： 10623879     DOI： 10.1002/(SICI)1097-4652(200002)182:2<163::AID-JCP4>3.0.CO;2-1

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  29 in total

Review 1.  Glutathione and modulation of cell apoptosis.

Authors:  Magdalena L Circu; Tak Yee Aw
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2.  Mechanisms of gamma-glutamylcysteine ligase regulation.

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Journal:  Biochim Biophys Acta       Date:  2005-11-17

3.  Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death.

Authors:  Christopher C Franklin; Cecile M Krejsa; Robert H Pierce; Collin C White; Nelson Fausto; Terrance J Kavanagh
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Review 4.  Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.

Authors:  Christopher C Franklin; Donald S Backos; Isaac Mohar; Collin C White; Henry J Forman; Terrance J Kavanagh
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5.  Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease.

Authors:  Joanne L Rodford; Christopher Torrens; Richard C M Siow; Giovanni E Mann; Mark A Hanson; Geraldine F Clough
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6.  Oxidative stress and glutathione response in tissue cultures from persons with major depression.

Authors:  Sara A Gibson; Željka Korade; Richard C Shelton
Journal:  J Psychiatr Res       Date:  2012-07-28       Impact factor: 4.791

7.  Renal antioxidant enzymes and glutathione redox status in leptin-induced hypertension.

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8.  Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione.

Authors:  Gennaro Giordano; Terrance J Kavanagh; Elaine M Faustman; Collin C White; Lucio G Costa
Journal:  Toxicol Sci       Date:  2013-01-12       Impact factor: 4.849

9.  Crystal structure of gamma-glutamylcysteine synthetase: insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis.

Authors:  Takao Hibi; Hiroshi Nii; Toru Nakatsu; Akira Kimura; Hiroaki Kato; Jun Hiratake; Jun'ichi Oda
Journal:  Proc Natl Acad Sci U S A       Date:  2004-10-11       Impact factor: 11.205

10.  Impaired glutathione synthesis in schizophrenia: convergent genetic and functional evidence.

Authors:  René Gysin; Rudolf Kraftsik; Julie Sandell; Pierre Bovet; Céline Chappuis; Philippe Conus; Patricia Deppen; Martin Preisig; Viviane Ruiz; Pascal Steullet; Mirjana Tosic; Thomas Werge; Michel Cuénod; Kim Q Do
Journal:  Proc Natl Acad Sci U S A       Date:  2007-10-05       Impact factor: 11.205
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