Literature DB >> 10622748

Identification of the mitochondrial carnitine carrier in Saccharomyces cerevisiae.

L Palmieri1, F M Lasorsa, V Iacobazzi, M J Runswick, F Palmieri, J E Walker.   

Abstract

The mitochondrial carrier protein for carnitine has been identified in Saccharomyces cerevisiae. It is encoded by the gene CRC1 and is a member of the family of mitochondrial transport proteins. The protein has been over-expressed with a C-terminal His-tag in S. cerevisiae and isolated from mitochondria by nickel affinity chromatography. The purified protein has been reconstituted into proteoliposomes and its transport characteristics established. It transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines.

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Year:  1999        PMID： 10622748     DOI： 10.1016/s0014-5793(99)01555-0

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  32 in total

1.  The Saccharomyces cerevisiae ICL2 gene encodes a mitochondrial 2-methylisocitrate lyase involved in propionyl-coenzyme A metabolism.

Authors:  M A Luttik; P Kötter; F A Salomons; I J van der Klei; J P van Dijken; J T Pronk
Journal:  J Bacteriol       Date:  2000-12       Impact factor: 3.490

2.  Functional expression of eukaryotic membrane proteins in Lactococcus lactis.

Authors:  Magnus Monné; Ka Wai Chan; Dirk-Jan Slotboom; Edmund R S Kunji
Journal:  Protein Sci       Date:  2005-10-31       Impact factor: 6.725

3.  The mechanism of transport by mitochondrial carriers based on analysis of symmetry.

Authors:  Alan J Robinson; Catherine Overy; Edmund R S Kunji
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-10       Impact factor: 11.205

Review 4.  Physiological and pathological roles of mitochondrial SLC25 carriers.

Authors:  Manuel Gutiérrez-Aguilar; Christopher P Baines
Journal:  Biochem J       Date:  2013-09-15       Impact factor: 3.857

5.  The human gene SLC25A29, of solute carrier family 25, encodes a mitochondrial transporter of basic amino acids.

Authors:  Vito Porcelli; Giuseppe Fiermonte; Antonella Longo; Ferdinando Palmieri
Journal:  J Biol Chem       Date:  2014-03-20       Impact factor: 5.157

6.  Substrate specificity of the two mitochondrial ornithine carriers can be swapped by single mutation in substrate binding site.

Authors:  Magnus Monné; Daniela Valeria Miniero; Lucia Daddabbo; Alan J Robinson; Edmund R S Kunji; Ferdinando Palmieri
Journal:  J Biol Chem       Date:  2012-01-19       Impact factor: 5.157

7.  Overproduction of threonine aldolase circumvents the biosynthetic role of pyruvate decarboxylase in glucose-limited chemostat cultures of Saccharomyces cerevisiae.

Authors:  Antonius J A van Maris; Marijke A H Luttik; Aaron A Winkler; Johannes P van Dijken; Jack T Pronk
Journal:  Appl Environ Microbiol       Date:  2003-04       Impact factor: 4.792

8.  Does any yeast mitochondrial carrier have a native uncoupling protein function?

Authors:  Damien Roussel; Marilyn Harding; Michael J Runswick; John E Walker; Martin D Brand
Journal:  J Bioenerg Biomembr       Date:  2002-06       Impact factor: 2.945

Review 9.  Lysine acetylation in the lumen of the ER: a novel and essential function under the control of the UPR.

Authors:  Mariana Pehar; Luigi Puglielli
Journal:  Biochim Biophys Acta       Date:  2012-12-13

10.  Uncoupling proteins 1 and 2 (UCP1 and UCP2) from Arabidopsis thaliana are mitochondrial transporters of aspartate, glutamate, and dicarboxylates.

Authors:  Magnus Monné; Lucia Daddabbo; David Gagneul; Toshihiro Obata; Björn Hielscher; Luigi Palmieri; Daniela Valeria Miniero; Alisdair R Fernie; Andreas P M Weber; Ferdinando Palmieri
Journal:  J Biol Chem       Date:  2018-01-25       Impact factor: 5.157
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