Literature DB >> 10622723

Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin.

J Hellwage1, T S Jokiranta, V Koistinen, O Vaarala, S Meri, P F Zipfel.   

Abstract

The human factor H-related proteins FHR-3 and FHR4 are members of a family of proteins related to the complement factor H. Here, we report that the two proteins bind to the C3d region of complement C3b. The apparent K(A) values for the interactions of FHR-3 and FHR-4 with C3b are 7.5 x 10(6) M(-1) and 2.9 x 10(6) M(-1), respectively. Binding studies performed with C3b-coated pneumococci confirmed the results obtained with the biosensor system. A C-terminal construct of factor H showed similar binding characteristics. The interaction of FHR-3, but not of FHR4, with opsonised pneumococci was inhibited by heparin.

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Year:  1999        PMID： 10622723     DOI： 10.1016/s0014-5793(99)01554-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  48 in total

Review 1.  Complement activation, regulation, and molecular basis for complement-related diseases.

Authors:  Goran Bajic; Søren E Degn; Steffen Thiel; Gregers R Andersen
Journal:  EMBO J       Date:  2015-10-21       Impact factor: 11.598

2.  LfhA, a novel factor H-binding protein of Leptospira interrogans.

Authors:  Ashutosh Verma; Jens Hellwage; Sergey Artiushin; Peter F Zipfel; Peter Kraiczy; John F Timoney; Brian Stevenson
Journal:  Infect Immun       Date:  2006-05       Impact factor: 3.441

3.  FHR4-based immunoconjugates direct complement-dependent cytotoxicity and phagocytosis towards HER2-positive cancer cells.

Authors:  Carole Seguin-Devaux; Jean-Marc Plesseria; Charlène Verschueren; Cécile Masquelier; Gilles Iserentant; Marie Fullana; Mihály Józsi; Jacques H M Cohen; Xavier Dervillez
Journal:  Mol Oncol       Date:  2019-09-30       Impact factor: 6.603

4.  Complement factor H-related hybrid protein deregulates complement in dense deposit disease.

Authors:  Qian Chen; Michael Wiesener; Hannes U Eberhardt; Andrea Hartmann; Barbara Uzonyi; Michael Kirschfink; Kerstin Amann; Maike Buettner; Tim Goodship; Christian Hugo; Christine Skerka; Peter F Zipfel
Journal:  J Clin Invest       Date:  2013-12-16       Impact factor: 14.808

5.  Complement Factor H-Related 5-Hybrid Proteins Anchor Properdin and Activate Complement at Self-Surfaces.

Authors:  Qian Chen; Melanie Manzke; Andrea Hartmann; Maike Büttner; Kerstin Amann; Diana Pauly; Michael Wiesener; Christine Skerka; Peter F Zipfel
Journal:  J Am Soc Nephrol       Date:  2015-10-02       Impact factor: 10.121

6.  Manifestation of atypical hemolytic uremic syndrome caused by novel mutations in MCP.

Authors:  Dana Provaznikova; Simon Rittich; Michal Malina; Tomas Seeman; Iuri Marinov; Magdalena Riedl; Ingrid Hrachovinova
Journal:  Pediatr Nephrol       Date:  2011-06-27       Impact factor: 3.714

7.  Modulation of the Alternative Pathway of Complement by Murine Factor H-Related Proteins.

Authors:  Alexandra H Antonioli; Janice White; Frances Crawford; Brandon Renner; Kevin J Marchbank; Jonathan P Hannan; Joshua M Thurman; Philippa Marrack; V Michael Holers
Journal:  J Immunol       Date:  2017-11-29       Impact factor: 5.422

8.  Dimerization of complement factor H-related proteins modulates complement activation in vivo.

Authors:  Elena Goicoechea de Jorge; Joseph J E Caesar; Talat H Malik; Mitali Patel; Matthew Colledge; Steven Johnson; Svetlana Hakobyan; B Paul Morgan; Claire L Harris; Matthew C Pickering; Susan M Lea
Journal:  Proc Natl Acad Sci U S A       Date:  2013-03-04       Impact factor: 11.205

Review 9.  Anti-complement-factor H-associated glomerulopathies.

Authors:  Marie-Agnes Dragon Durey; Aditi Sinha; Shambhuprasad Kotresh Togarsimalemath; Arvind Bagga
Journal:  Nat Rev Nephrol       Date:  2016-07-25       Impact factor: 28.314

Review 10.  Borrelia burgdorferi complement regulator-acquiring surface proteins (BbCRASPs): Expression patterns during the mammal-tick infection cycle.

Authors:  Tomasz Bykowski; Michael E Woodman; Anne E Cooley; Catherine A Brissette; Reinhard Wallich; Volker Brade; Peter Kraiczy; Brian Stevenson
Journal:  Int J Med Microbiol       Date:  2007-12-31       Impact factor: 3.473
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