Hepatitis C virus infection in special groups.

Hepatitis C virus (HCV) infection is associated with a wide spectrum of clinical manifestations which may influence the choice of diagnostic assays, especially in haemodialysis patients, the clinical course of infection with possible multiple and sequential episodes of hepatitis in multiple transfused patients, and the severity of liver disease, especially in patients with HBV-HCV co-infection. The consequences of HCV infection in patients with organ graft are not completely understood due to the complexity of the clinical situations and the unavailability of long-term follow-up. Furthermore, current antiviral therapy is not very effective in these populations. Thus, it is especially important to protect patients at risk for HCV infection, using universal precautionary procedures.