Literature DB >> 10622439

Characterization of hemolytic activity of 3-alkylpyridinium polymers from the marine sponge Reniera sarai.

P Malovrh1, K Sepcić, T Turk, P Macek.   

Abstract

Polymeric alkylpyridinium salts (poly-APS) isolated from the marine sponge Reniera sarai act as potent anticholinesterase agents; in addition they show moderate hemolytic and cytotoxic activities. The hemolytic activity of poly-APS is due to their detergent-like structure and behavior in aqueous solutions. In this work, the hemolytic activity of poly-APS is analyzed and compared to that of structurally-related monomeric cationic surfactants. The influence of different divalent cations and lipids on poly-APS induced hemolysis is discussed. The dimensions of lesions caused by poly-APS in erythrocyte membranes are determined by the use of osmotic protectants. Finally, the possible role of poly-APS in their natural environment is proposed.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10622439     DOI： 10.1016/s0742-8413(99)00067-5

Source DB:  PubMed          Journal:  Comp Biochem Physiol C Pharmacol Toxicol Endocrinol        ISSN： 1367-8280


  10 in total

1.  Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits.

Authors:  Dave J Koss; Lianne Robinson; Anna Mietelska-Porowska; Anna Gasiorowska; Kristina Sepčić; Tom Turk; Marcel Jaspars; Grazyna Niewiadomska; Roderick H Scott; Bettina Platt; Gernot Riedel
Journal:  Cell Mol Life Sci       Date:  2015-06-13       Impact factor: 9.261

2.  Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins.

Authors:  Wael E Houssen; Zhibao Lu; Ruangelie Edrada-Ebel; Christina Chatzi; Steven J Tucker; Kristina Sepčić; Tom Turk; Ana Zovko; Sanbing Shen; Ines Mancini; Roderick H Scott; Marcel Jaspars
Journal:  J Chem Biol       Date:  2010-02-17

3.  Irreversible and reversible pore formation by polymeric alkylpyridinium salts (poly-APS) from the sponge Reniera sarai.

Authors:  D McClelland; R M Evans; I Abidin; S Sharma; F Z Choudhry; M Jaspars; K Sepcić; R H Scott
Journal:  Br J Pharmacol       Date:  2003-08       Impact factor: 8.739

4.  A comparative study of the actions of alkylpyridinium salts from a marine sponge and related synthetic compounds in rat cultured hippocampal neurones.

Authors:  David J Koss; Kathleen P Hindley; Kanola C David; Ines Mancini; Graziano Guella; Kristina Sepcić; Tom Turk; Katja Rebolj; Gernot Riedel; Bettina Platt; Roderick H Scott
Journal:  BMC Pharmacol       Date:  2007-02-02

Review 5.  Pathophysiological effects of synthetic derivatives of polymeric alkylpyridinium salts from the marine sponge, Reniera sarai.

Authors:  Marjana Grandič; Robert Frangež
Journal:  Mar Drugs       Date:  2014-04-30       Impact factor: 5.118

6.  Zinc treatment is efficient against Escherichia coli α-haemolysin-induced intestinal leakage in mice.

Authors:  Stephanie Wiegand; Silke S Zakrzewski; Miriam Eichner; Emanuel Schulz; Dorothee Günzel; Robert Pieper; Rita Rosenthal; Christian Barmeyer; André Bleich; Ulrich Dobrindt; Jörg-Dieter Schulzke; Roland Bücker
Journal:  Sci Rep       Date:  2017-03-31       Impact factor: 4.379

Review 7.  Natural Products from the Marine Sponge Subgenus Reniera.

Authors:  Xuelian Bai; Yang Liu; Hao Wang; Huawei Zhang
Journal:  Molecules       Date:  2021-02-19       Impact factor: 4.411

8.  Mechanisms of toxicity of 3-alkylpyridinium polymers from marine sponge Reniera sarai.

Authors:  Tom Turk; Robert Frangez; Kristina Sepcić
Journal:  Mar Drugs       Date:  2007-11-13       Impact factor: 5.118

9.  Identification of two novel cytolysins from the hydrozoan Olindias sambaquiensis (Cnidaria).

Authors:  Vidal Haddad Junior; Fernando Zara; Sergio Marangoni; Daniela de Oliveira Toyama; Alex Jardelino Felizardo de Souza; Simone Cristina Buzzo de Oliveira; Marcos Hikari Toyama
Journal:  J Venom Anim Toxins Incl Trop Dis       Date:  2014-03-25

10.  Antifouling activity of synthetic alkylpyridinium polymers using the barnacle model.

Authors:  Veronica Piazza; Ivanka Dragić; Kristina Sepčić; Marco Faimali; Francesca Garaventa; Tom Turk; Sabina Berne
Journal:  Mar Drugs       Date:  2014-04-02       Impact factor: 5.118
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.