Literature DB >> 10620296

Reverse mode of the sarcoplasmic reticulum calcium pump and load-dependent cytosolic calcium decline in voltage-clamped cardiac ventricular myocytes.

T R Shannon1, K S Ginsburg, D M Bers.   

Abstract

We have characterized [Ca](i) decline in voltage-clamped rabbit ventricular myocytes with progressive increases in sarcoplasmic reticulum (SR) calcium load. "Backflux" through the SR calcium pump is a critical feature which allows realistically small values for SR calcium leak fluxes to be used. Total cytosolic calcium was calculated from the latter part of [Ca](i) decline using rate constants for cellular calcium buffers. Intra-SR calcium buffering characteristics were also deduced. We found that the net SR calcium pump flux and rate of [Ca](i) decline decreased as the SR free [Ca] rose, with pump parameters held constant. We have therefore characterized for the first time in intact myocytes both forward and reverse SR calcium pump kinetics as well as intra-SR calcium buffering and SR calcium leak. We conclude that the reverse flux through the SR calcium pump is an important factor in comprehensive understanding of dynamic SR calcium fluxes.

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Year:  2000        PMID： 10620296      PMCID： PMC1300640          DOI： 10.1016/S0006-3495(00)76595-7

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  51 in total

1.  Ca2+ feedback on "quantal" Ca2+ release involving ryanodine receptors.

Authors:  C Dettbarn; P Palade
Journal:  Mol Pharmacol       Date:  1997-12       Impact factor: 4.436

2.  The kinetics of calcium binding to fura-2 and indo-1.

Authors:  A P Jackson; M P Timmerman; C R Bagshaw; C C Ashley
Journal:  FEBS Lett       Date:  1987-05-25       Impact factor: 4.124

3.  Ca2+ binding effects on protein conformation and protein interactions of canine cardiac calsequestrin.

Authors:  R D Mitchell; H K Simmerman; L R Jones
Journal:  J Biol Chem       Date:  1988-01-25       Impact factor: 5.157

4.  Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes.

Authors:  J W Bassani; W Yuan; D M Bers
Journal:  Am J Physiol       Date:  1995-05

5.  Calibration of indo-1 and resting intracellular [Ca]i in intact rabbit cardiac myocytes.

Authors:  J W Bassani; R A Bassani; D M Bers
Journal:  Biophys J       Date:  1995-04       Impact factor: 4.033

6.  Intrinsic cytosolic calcium buffering properties of single rat cardiac myocytes.

Authors:  J R Berlin; J W Bassani; D M Bers
Journal:  Biophys J       Date:  1994-10       Impact factor: 4.033

7.  Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes.

Authors:  L F Santana; E G Kranias; W J Lederer
Journal:  J Physiol       Date:  1997-08-15       Impact factor: 5.182

8.  Sarcoplasmic reticulum Ca2+ uptake and thapsigargin sensitivity in permeabilized rabbit and rat ventricular myocytes.

Authors:  L Hove-Madsen; D M Bers
Journal:  Circ Res       Date:  1993-11       Impact factor: 17.367

9.  Control of sarcoplasmic reticulum calcium release during calcium loading in isolated rat ventricular myocytes.

Authors:  C I Spencer; J R Berlin
Journal:  J Physiol       Date:  1995-10-15       Impact factor: 5.182

10.  Calcium fluxes across the membrane of sarcoplasmic reticulum vesicles.

Authors:  H Takenaka; P N Adler; A M Katz
Journal:  J Biol Chem       Date:  1982-11-10       Impact factor: 5.157
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  62 in total

1.  Model of intracellular calcium cycling in ventricular myocytes.

Authors:  Y Shiferaw; M A Watanabe; A Garfinkel; J N Weiss; A Karma
Journal:  Biophys J       Date:  2003-12       Impact factor: 4.033

2.  A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.

Authors:  Thomas R Shannon; Fei Wang; José Puglisi; Christopher Weber; Donald M Bers
Journal:  Biophys J       Date:  2004-09-03       Impact factor: 4.033

3.  Phospholamban phosphorylation increases the passive calcium leak from cardiac sarcoplasmic reticulum.

Authors:  Roozbeh Aschar-Sobbi; Teresa L Emmett; Gary J Kargacin; Margaret E Kargacin
Journal:  Pflugers Arch       Date:  2012-07-07       Impact factor: 3.657

4.  Ca sparks do not explain all ryanodine receptor-mediated SR Ca leak in mouse ventricular myocytes.

Authors:  Demetrio J Santiago; Jerald W Curran; Donald M Bers; W J Lederer; Michael D Stern; Eduardo Ríos; Thomas R Shannon
Journal:  Biophys J       Date:  2010-05-19       Impact factor: 4.033

5.  Sarcoplasmic Reticulum Structure and Functional Properties that Promote Long-Lasting Calcium Sparks.

Authors:  Daisuke Sato; Thomas R Shannon; Donald M Bers
Journal:  Biophys J       Date:  2016-01-19       Impact factor: 4.033

6.  Phosphorylation of cardiac myosin-binding protein-C contributes to calcium homeostasis.

Authors:  Mohit Kumar; Kobra Haghighi; Evangelia G Kranias; Sakthivel Sadayappan
Journal:  J Biol Chem       Date:  2020-06-18       Impact factor: 5.157

7.  Phospholemman is a negative feed-forward regulator of Ca2+ in β-adrenergic signaling, accelerating β-adrenergic inotropy.

Authors:  Jason H Yang; Jeffrey J Saucerman
Journal:  J Mol Cell Cardiol       Date:  2012-01-20       Impact factor: 5.000

8.  Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.

Authors:  Lili Wang; Kyungsoo Kim; Shan Parikh; Adrian Gabriel Cadar; Kevin R Bersell; Huan He; Jose R Pinto; Dmytro O Kryshtal; Bjorn C Knollmann
Journal:  J Mol Cell Cardiol       Date:  2017-12-05       Impact factor: 5.000

9.  Automated analysis of contractile force and Ca2+ transients in engineered heart tissue.

Authors:  Andrea Stoehr; Christiane Neuber; Christina Baldauf; Ingra Vollert; Felix W Friedrich; Frederik Flenner; Lucie Carrier; Alexandra Eder; Sebastian Schaaf; Marc N Hirt; Bülent Aksehirlioglu; Carl W Tong; Alessandra Moretti; Thomas Eschenhagen; Arne Hansen
Journal:  Am J Physiol Heart Circ Physiol       Date:  2014-02-28       Impact factor: 4.733

10.  Mechanisms underlying angiotensin II-induced calcium oscillations.

Authors:  Aurélie Edwards; Thomas L Pallone
Journal:  Am J Physiol Renal Physiol       Date:  2008-06-18
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