Literature DB >> 10619644

Up- and down-regulation of BDNF mRNA in distinct subgroups of rat sensory neurons after axotomy.

H Kashiba1, E Senba.   

Abstract

Anterograde transport of BDNF is enhanced by axotomy in the rat sciatic nerve. However, the changes in BDNF gene expression in dorsal root ganglion (DRG) neurons after axotomy are not known. We examined this issue using in situ hybridization histochemistry. BDNF mRNA was detected in 35-40% of DRG neurons (L5) of control rats. Most of these neurons are small. BDNF gene expression in these neurons was down-regulated after application of capsaicin to the sciatic nerve. Transection of the sciatic nerve induced the up-regulation of BDNF mRNA. The intensely labeled neurons were mainly large and immunoreactive for neuropeptide Y. These results suggest that up- and down-regulation of BDNF gene expression in distinct subgroups of rat DRG neurons are caused by damage to the peripheral nerve.

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Year:  1999        PMID： 10619644     DOI： 10.1097/00001756-199911260-00018

Source DB:  PubMed          Journal:  Neuroreport        ISSN： 0959-4965            Impact factor:   1.837


  7 in total

1.  Upregulation of brain-derived neurotrophic factor in the sensory pathway by selective motor nerve injury in adult rats.

Authors:  Li Li; Cory J Xian; Jin-Hua Zhong; Xin-Fu Zhou
Journal:  Neurotox Res       Date:  2006-06       Impact factor: 3.911

2.  Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model.

Authors:  T Fukuoka; E Kondo; Y Dai; N Hashimoto; K Noguchi
Journal:  J Neurosci       Date:  2001-07-01       Impact factor: 6.167

3.  The protective effects of Achyranthes bidentata polypeptides on rat sciatic nerve crush injury causes modulation of neurotrophic factors.

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Journal:  Neurochem Res       Date:  2012-12-15       Impact factor: 3.996

4.  Characterization of dendritic morphology and neurotransmitter phenotype of thoracic descending propriospinal neurons after complete spinal cord transection and GDNF treatment.

Authors:  Lingxiao Deng; Yiwen Ruan; Chen Chen; Christian Corbin Frye; Wenhui Xiong; Xiaoming Jin; Kathryn Jones; Dale Sengelaub; Xiao-Ming Xu
Journal:  Exp Neurol       Date:  2015-12-28       Impact factor: 5.330

Review 5.  Contribution of the spared primary afferent neurons to the pathomechanisms of neuropathic pain.

Authors:  Tetsuo Fukuoka; Koichi Noguchi
Journal:  Mol Neurobiol       Date:  2002-08       Impact factor: 5.590

6.  Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury.

Authors:  Michael Costigan; Katia Befort; Laurie Karchewski; Robert S Griffin; Donatella D'Urso; Andrew Allchorne; Joanne Sitarski; James W Mannion; Richard E Pratt; Clifford J Woolf
Journal:  BMC Neurosci       Date:  2002-10-25       Impact factor: 3.288

7.  Why It Is Necessary to Use the Entire Root rather than Partial Root When Doing Contralateral C7 Nerve Transfer: Cortical Plasticity Also Matters besides the Amount of Nerve Fibers.

Authors:  Jinding Guo; Xin Zhao; Jie Lao; Kaiming Gao
Journal:  Neural Plast       Date:  2021-01-04       Impact factor: 3.599
  7 in total

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