| Literature DB >> 10619430 |
F A Chaudhry1, R J Reimer, D Krizaj, D Barber, J Storm-Mathisen, D R Copenhagen, R H Edwards.
Abstract
The amino acid glutamine has a central role in nitrogen metabolism. Although the molecular mechanisms responsible for its transport across cell membranes remain poorly understood, classical amino acid transport system N appears particularly important. Using intracellular pH measurements, we have now identified an orphan protein related to a vesicular neurotransmitter transporter as system N. Functional analysis shows that this protein (SN1) involves H+ exchange as well as Na+ cotransport and, under physiological conditions, mediates glutamine efflux as well as uptake. Together with the pattern of SN1 expression, these unusual properties suggest novel physiological roles for system N in nitrogen metabolism and synaptic transmission.Entities:
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Year: 1999 PMID： 10619430 DOI： 10.1016/s0092-8674(00)81674-8
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582