Literature DB >> 10618567

Management of heart failure among very old persons living in long-term care: has the voice of trials spread? The SAGE Study Group.

G Gambassi1, D E Forman, K L Lapane, V Mor, A Sgadari, L A Lipsitz, R Bernabei.   

Abstract

BACKGROUND: Increasing prevalence, use of health services, and number of deaths have made congestive heart failure (CHF) a new epidemic in the United States. Yet there are no adequate data to guide treatment of the more typical and complex cases of patients who are very old and frail.
METHODS: Using the SAGE database, we studied the cases of 86,094 patients with CHF admitted to any of the 1492 long-term care facilities of 5 states from 1992 through 1996. We described their clinical and functional characteristics and their pharmacologic treatment to verify agreement with widely approved guidelines. We evaluated age- and sex-related differences, and we determined predictors of receiving an angiotensin-converting enzyme (ACE) inhibitor by developing a multiple logistic regression model.
RESULTS: The mean age of the population was 84.9 +/- 8 years. Eighty percent of the patients 85 years of age or older were women. More than two thirds of patients underwent frequent hospitalizations related to CHF in the year preceding admission to a long-term care facility. Coronary heart disease and hypertension were the most common causes. Half of the patients received digoxin and 45% a diuretic, regardless of background cardiovascular comorbidities. Only 25% of patients had a prescription for ACE inhibitors. The presence of cardiovascular comorbidity, already being a recipient of a large number of medications, a previous hospitalization for CHF, and admission to the facility in recent years were associated with an increased likelihood of receiving an ACE inhibitor. The presence of severe physical limitation was inversely related to use of ACE inhibitors, as were a series of organizational factors related to the facilities.
CONCLUSIONS: Patients in long-term care who have CHF little resemble to those enrolled in randomized trials. This circumstance may explain, at least in part, the divergence from pharmacologic management consensus guidelines. Yet the prescription of ACE inhibitors varies significantly across facilities and depends on organizational characteristics.

Entities:  

Mesh:

Substances:

Year:  2000        PMID: 10618567     DOI: 10.1016/s0002-8703(00)90313-2

Source DB:  PubMed          Journal:  Am Heart J        ISSN: 0002-8703            Impact factor:   4.749


  28 in total

Review 1.  The drive for quality care in US nursing homes in the era of the prospective payment system.

Authors:  Carmel M Hughes; Kate L Lapane
Journal:  Drugs Aging       Date:  2002       Impact factor: 3.923

2.  Inappropriate medication use among hospitalized older adults in Italy: results from the Italian Group of Pharmacoepidemiology in the Elderly.

Authors:  Graziano Onder; Francesco Landi; Matteo Cesari; Giovanni Gambassi; Pierugo Carbonin; Roberto Bernabei
Journal:  Eur J Clin Pharmacol       Date:  2003-05-07       Impact factor: 2.953

Review 3.  Administrative initiatives for reducing inappropriate prescribing of psychotropic drugs in nursing homes: how successful have they been?

Authors:  Carmel M Hughes; Kate L Lapane
Journal:  Drugs Aging       Date:  2005       Impact factor: 3.923

4.  Improving use of medicines for older people in long-term care: contrasting the policy approach of four countries.

Authors:  Carmel M Hughes; Elizabeth Roughead; Ngaire Kerse
Journal:  Healthc Policy       Date:  2008-02

Review 5.  Heart failure in very old adults.

Authors:  Daniel E Forman; Ali Ahmed; Jerome L Fleg
Journal:  Curr Heart Fail Rep       Date:  2013-12

6.  Use of nesiritide before and after publications suggesting drug-related risks in patients with acute decompensated heart failure.

Authors:  Paul J Hauptman; Mark A Schnitzler; Jason Swindle; Thomas E Burroughs
Journal:  JAMA       Date:  2006-10-18       Impact factor: 56.272

7.  Evaluation of prescriber responses to pharmacist recommendations communicated by fax in a medication therapy management program (MTMP).

Authors:  Prasadini N Perera; Mignonne C Guy; Ashley M Sweaney; Kevin P Boesen
Journal:  J Manag Care Pharm       Date:  2011-06

8.  Perindopril improves six minute walking distance in older patients with left ventricular systolic dysfunction: a randomised double blind placebo controlled trial.

Authors:  S D Hutcheon; N D Gillespie; I K Crombie; A D Struthers; M E T McMurdo
Journal:  Heart       Date:  2002-10       Impact factor: 5.994

9.  Who are they? Patients with heart failure in American skilled nursing facilities.

Authors:  Lin Li; Bill M Jesdale; Anne Hume; Giovanni Gambassi; Robert J Goldberg; Kate L Lapane
Journal:  J Cardiol       Date:  2017-10-28       Impact factor: 3.159

10.  A randomized trial of heart failure disease management in skilled nursing facilities: design and rationale.

Authors:  Rebecca S Boxer; Mary A Dolansky; Christine A Bodnar; Mendel E Singer; Jeffery M Albert; Stefan Gravenstein
Journal:  J Am Med Dir Assoc       Date:  2013-07-18       Impact factor: 4.669

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.