Literature DB >> 10618540

Paraflagellar rod proteins administered with alum and IL-12 or recombinant adenovirus expressing IL-12 generates antigen-specific responses and protective immunity in mice against Trypanosoma cruzi.

R A Wrightsman1, J E Manning.   

Abstract

Successful vaccination of mice against an otherwise lethal challenge with the Peru strain of Trypanosoma cruzi necessitates the induction of a strong cell mediated immune response. Previously, immunization of mice with the paraflagellar rod proteins from Trypanosoma cruzi90% reduction in parasitemia in immunized mice challenged with the bloodstream stage of Trypanosoma cruzi.

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Year:  2000        PMID： 10618540     DOI： 10.1016/s0264-410x(99)00380-1

Source DB:  PubMed          Journal:  Vaccine        ISSN： 0264-410X            Impact factor:   3.641


  12 in total

Review 1.  An overview on kinetoplastid paraflagellar rod.

Authors:  B R Maharana; A K Tewari; Veer Singh
Journal:  J Parasit Dis       Date:  2014-02-07

2.  CD8+-T-cell-dependent control of Trypanosoma cruzi infection in a highly susceptible mouse strain after immunization with recombinant proteins based on amastigote surface protein 2.

Authors:  Adriano F S Araújo; Bruna C G de Alencar; José Ronnie C Vasconcelos; Meire I Hiyane; Cláudio R F Marinho; Marcus L O Penido; Silvia B Boscardin; Daniel F Hoft; Ricardo T Gazzinelli; Mauricio M Rodrigues
Journal:  Infect Immun       Date:  2005-09       Impact factor: 3.441

3.  Cloning and expression analysis of two novel paraflagellar rod domain genes found in Trypanosoma cruzi.

Authors:  April K Clark; Gennadiy Kovtunovych; Sachin Kandlikar; Shailesh Lal; Gabrielle A Stryker
Journal:  Parasitol Res       Date:  2005-05-26       Impact factor: 2.289

4.  Proteomics of Trypanosoma evansi infection in rodents.

Authors:  Nainita Roy; Rishi Kumar Nageshan; Rani Pallavi; Harshini Chakravarthy; Syama Chandran; Rajender Kumar; Ashok Kumar Gupta; Raj Kumar Singh; Suresh Chandra Yadav; Utpal Tatu
Journal:  PLoS One       Date:  2010-03-22       Impact factor: 3.240

Review 5.  The paraflagellar rod of kinetoplastid parasites: from structure to components and function.

Authors:  Neil Portman; Keith Gull
Journal:  Int J Parasitol       Date:  2009-10-30       Impact factor: 3.981

6.  Novel protective antigens expressed by Trypanosoma cruzi amastigotes provide immunity to mice highly susceptible to Chagas' disease.

Authors:  Eduardo L V Silveira; Carla Claser; Filipe A B Haolla; Luiz G Zanella; Mauricio M Rodrigues
Journal:  Clin Vaccine Immunol       Date:  2008-06-25

7.  Humoral and cellular immune responses to Trypanosoma cruzi-derived paraflagellar rod proteins in patients with Chagas' disease.

Authors:  Vladimir Michailowsky; Keith Luhrs; Manoel Otávio C Rocha; David Fouts; Ricardo T Gazzinelli; Jerry E Manning
Journal:  Infect Immun       Date:  2003-06       Impact factor: 3.441

8.  Coadministration of an interleukin-12 gene and a Trypanosoma cruzi gene improves vaccine efficacy.

Authors:  Masaharu Katae; Yasushi Miyahira; Kazuyoshi Takeda; Hironori Matsuda; Hideo Yagita; Ko Okumura; Tsutomu Takeuchi; Tsuneo Kamiyama; Akihiko Ohwada; Yoshinosuke Fukuchi; Takashi Aoki
Journal:  Infect Immun       Date:  2002-09       Impact factor: 3.441

9.  Immunization with Hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection.

Authors:  Anitra L Farrow; Girish Rachakonda; Linlin Gu; Valentina Krendelchtchikova; Pius N Nde; Siddharth Pratap; Maria F Lima; Fernando Villalta; Qiana L Matthews
Journal:  PLoS Negl Trop Dis       Date:  2014-08-21

10.  Generation of a nanobody targeting the paraflagellar rod protein of trypanosomes.

Authors:  Emmanuel Obishakin; Benoit Stijlemans; Julien Santi-Rocca; Isabel Vandenberghe; Bart Devreese; Serge Muldermans; Philippe Bastin; Stefan Magez
Journal:  PLoS One       Date:  2014-12-31       Impact factor: 3.240
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