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Literature DB >> 10618388

Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice.

E R Travis¹, Y M Wang, D J Michael, M G Caron, R M Wightman.

Abstract

The recent availability of mice lacking the neuronal form of the vesicular monoamine transporter 2 (VMAT2) affords the opportunity to study its roles in storage and release. Carbon fiber microelectrodes were used to measure individual secretory events of histamine and 5-hydroxytryptamine (5-HT) from VMAT2-expressing mast cells as a model system for quantal release. VMAT2 is indispensable for monoamine storage because mast cells from homozygous (VMAT2(-/-)) mice, while undergoing granule-cell fusion, do not release monoamines. Cells from heterozygous animals (VMAT2(+/-)) secrete lower amounts of monoamine per granule than cells from wild-type controls. Investigation of corelease of histamine and 5-HT from granules in VMAT2(+/-) cells revealed 5-HT quantal size was reduced more than that of histamine. Thus, although vesicular transport is the limiting factor determining quantal size of 5-HT and histamine release, intragranular association with the heparin matrix also plays a significant role.

Entities: Chemical Gene Species

Mesh：

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Year: 2000 PMID： 10618388 PMCID： PMC26633 DOI： 10.1073/pnas.97.1.162

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

34 in total

1. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

Authors: N Takahashi; L L Miner; I Sora; H Ujike; R S Revay; V Kostic; V Jackson-Lewis; S Przedborski; G R Uhl
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

Review 2. How does a vesicle know it is full?

Authors: J Williams
Journal: Neuron Date: 1997-05 Impact factor: 17.173

Review 3. Pre- and postfusion regulation of transmitter release.

Authors: R Rahamimoff; J M Fernandez
Journal: Neuron Date: 1997-01 Impact factor: 17.173

4. Expression of a putative vesicular acetylcholine transporter facilitates quantal transmitter packaging.

Authors: H Song; G Ming; E Fon; E Bellocchio; R H Edwards; M Poo
Journal: Neuron Date: 1997-05 Impact factor: 17.173

Review 5. A molecular analysis of vesicular amine transport.

Authors: Y Liu; D Peter; A Merickel; D Krantz; J P Finn; R H Edwards
Journal: Behav Brain Res Date: 1996 Impact factor: 3.332

6. Reserpine- and tetrabenazine-sensitive transport of (3)H-histamine by the neuronal isoform of the vesicular monoamine transporter.

Authors: J D Erickson; L E Eiden; M K Schafer; E Weihe
Journal: J Mol Neurosci Date: 1995 Impact factor: 3.444

7. Kinetics of release of serotonin from isolated secretory granules. II. Ion exchange determines the diffusivity of serotonin.

Authors: P E Marszalek; B Farrell; P Verdugo; J M Fernandez
Journal: Biophys J Date: 1997-09 Impact factor: 4.033

Review 8. Vesicular neurotransmitter transporters. Potential sites for the regulation of synaptic function.

Authors: H Varoqui; J D Erickson
Journal: Mol Neurobiol Date: 1997-10 Impact factor: 5.590

9. Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action.

Authors: E A Fon; E N Pothos; B C Sun; N Killeen; D Sulzer; R H Edwards
Journal: Neuron Date: 1997-12 Impact factor: 17.173

10. Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine.

Authors: Y M Wang; R R Gainetdinov; F Fumagalli; F Xu; S R Jones; C B Bock; G W Miller; R M Wightman; M G Caron
Journal: Neuron Date: 1997-12 Impact factor: 17.173

19 in total

Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice.

1. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

Review 2. How does a vesicle know it is full?

Review 3. Pre- and postfusion regulation of transmitter release.

4. Expression of a putative vesicular acetylcholine transporter facilitates quantal transmitter packaging.

Review 5. A molecular analysis of vesicular amine transport.

6. Reserpine- and tetrabenazine-sensitive transport of (3)H-histamine by the neuronal isoform of the vesicular monoamine transporter.

7. Kinetics of release of serotonin from isolated secretory granules. II. Ion exchange determines the diffusivity of serotonin.

Review 8. Vesicular neurotransmitter transporters. Potential sites for the regulation of synaptic function.

9. Vesicular transport regulates monoamine storage and release but is not essential for amphetamine action.

10. Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine.

1. Synaptic vesicle transporter expression regulates vesicle phenotype and quantal size.

2. Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms.

3. In vivo histamine voltammetry in the mouse premammillary nucleus.

4. Munc-18-1 regulates the initial release rate of exocytosis.

Review 5. Recent advances in fast-scan cyclic voltammetry.

Review 6. Electroanalytical eavesdropping on single cell communication.

7. Mechanism of Histamine Oxidation and Electropolymerization at Carbon Electrodes.

8. Vesicle impact electrochemical cytometry compared to amperometric exocytosis measurements.

Review 9. VMAT2 gene expression and function as it applies to imaging beta-cell mass.

10. Ruthenium red colorimetric and birefringent staining of amyloid-β aggregates in vitro and in Tg2576 mice.