Literature DB >> 10617310

Rapid cortical hemoglobin deoxygenation after heroin and methadone injection in humans: a preliminary report.

R Stohler1, K M Dürsteler, R Störmer, E Seifritz, I Hug, J Sattler-Mayr, F Muller-Spahn, D Ladewig, C Hock.   

Abstract

The short-term effects of intravenous opioids (heroin 20-300 mg, methadone 30-180 mg) on cortical hemoglobin oxygenation were examined by near infrared spectroscopy in ten opioid-dependent subjects and were compared with the effects of saline in ten age-matched normal controls. Heroin and methadone produced a rapid and dramatic decrease in cortical hemoglobin oxygenation. Saline had no effects. Opioid-induced acute deoxygenation of cortical hemoglobin is most likely associated with respiratory depression. Thorough medical monitoring is strongly recommended in intravenous opioid maintenance treatments.

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Year:  1999        PMID： 10617310     DOI： 10.1016/s0376-8716(99)00036-8

Source DB:  PubMed          Journal:  Drug Alcohol Depend        ISSN： 0376-8716            Impact factor:   4.492


  8 in total

1.  Why we object to NAOMI. Heroin maintenance in Canada.

Authors:  Meldon Kahan; Anita Srivastava; Kay Shen
Journal:  Can Fam Physician       Date:  2006-06       Impact factor: 3.275

2.  Increased functional connectivity in the resting-state basal ganglia network after acute heroin substitution.

Authors:  A Schmidt; N Denier; S Magon; E-W Radue; C G Huber; A Riecher-Rossler; G A Wiesbeck; U E Lang; S Borgwardt; M Walter
Journal:  Transl Psychiatry       Date:  2015-03-24       Impact factor: 6.222

3.  Association of frontal gray matter volume and cerebral perfusion in heroin addiction: a multimodal neuroimaging study.

Authors:  Niklaus Denier; André Schmidt; Hana Gerber; Otto Schmid; Anita Riecher-Rössler; Gerhard A Wiesbeck; Christian G Huber; Undine E Lang; Ernst-Wilhelm Radue; Marc Walter; Stefan Borgwardt
Journal:  Front Psychiatry       Date:  2013-10-21       Impact factor: 4.157

4.  Normalizing effect of heroin maintenance treatment on stress-induced brain connectivity.

Authors:  André Schmidt; Marc Walter; Hana Gerber; Erich Seifritz; Rudolf Brenneisen; Gerhard A Wiesbeck; Anita Riecher-Rössler; Undine E Lang; Stefan Borgwardt
Journal:  Brain       Date:  2014-11-19       Impact factor: 13.501

5.  Using Functional Near-Infrared Spectroscopy to Measure Effects of Delta 9-Tetrahydrocannabinol on Prefrontal Activity and Working Memory in Cannabis Users.

Authors:  Hasan O Keles; Milena Radoman; Gladys N Pachas; A Eden Evins; Jodi M Gilman
Journal:  Front Hum Neurosci       Date:  2017-10-10       Impact factor: 3.169

6.  Rapid Physiological Fluctuations in Nucleus Accumbens Oxygen Levels Induced by Arousing Stimuli: Relationships with Changes in Brain Glucose and Metabolic Neural Activation.

Authors:  Ernesto Solis; Keaton T Cameron-Burr; Eugene A Kiyatkin
Journal:  Front Integr Neurosci       Date:  2017-04-24

7.  Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response.

Authors:  Ernesto Solis; Keaton T Cameron-Burr; Yavin Shaham; Eugene A Kiyatkin
Journal:  eNeuro       Date:  2017-06-07

8.  Inferior frontal cortex modulation with an acute dose of heroin during cognitive control.

Authors:  André Schmidt; Marc Walter; Hana Gerber; Otto Schmid; Renata Smieskova; Kerstin Bendfeldt; Gerhard A Wiesbeck; Anita Riecher-Rössler; Undine E Lang; Katya Rubia; Philip McGuire; Stefan Borgwardt
Journal:  Neuropsychopharmacology       Date:  2013-05-15       Impact factor: 7.853
  8 in total

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