Literature DB >> 10617089

Novel synthetic analogs of the Pseudomonas autoinducer.

T Kline1, J Bowman, B H Iglewski, T de Kievit, Y Kakai, L Passador.   

Abstract

Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-1 and PAI-2, that activate the respective transcription factors LasR and RhlR. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-1 and evaluated them in P. aeruginosa. Two of the novel analogs bound to LasR and showed agonist activity in LasR stimulation of a lasI-lacZ reporter construct.

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Year:  1999        PMID： 10617089     DOI： 10.1016/s0960-894x(99)00626-5

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  18 in total

1.  A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms.

Authors:  Hirotoshi Matsui; Victoria E Wagner; David B Hill; Ute E Schwab; Troy D Rogers; Brian Button; Russell M Taylor; Richard Superfine; Michael Rubinstein; Barbara H Iglewski; Richard C Boucher
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-20       Impact factor: 11.205

2.  Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment.

Authors:  Victoria E Wagner; Daniel Bushnell; Luciano Passador; Andrew I Brooks; Barbara H Iglewski
Journal:  J Bacteriol       Date:  2003-04       Impact factor: 3.490

3.  Computer-aided design of agents that inhibit the cep quorum-sensing system of Burkholderia cenocepacia.

Authors:  Kathrin Riedel; Manuela Köthe; Bernd Kramer; Wael Saeb; Astrid Gotschlich; Aldo Ammendola; Leo Eberl
Journal:  Antimicrob Agents Chemother       Date:  2006-01       Impact factor: 5.191

4.  Comparative analyses of N-acylated homoserine lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing.

Authors:  Grant D Geske; Jennifer C O'Neill; David M Miller; Rachel J Wezeman; Margrith E Mattmann; Qi Lin; Helen E Blackwell
Journal:  Chembiochem       Date:  2008-02-15       Impact factor: 3.164

5.  Small molecules that modulate quorum sensing and control virulence in Pseudomonas aeruginosa.

Authors:  Margrith E Mattmann; Helen E Blackwell
Journal:  J Org Chem       Date:  2010-10-15       Impact factor: 4.354

6.  Targeting the heat shock protein 90 dimer with dimeric inhibitors.

Authors:  Bhaskar Reddy Kusuma; Laura B Peterson; Huiping Zhao; George Vielhauer; Jeffrey Holzbeierlein; Brian S J Blagg
Journal:  J Med Chem       Date:  2011-08-23       Impact factor: 7.446

7.  Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa.

Authors:  M W Calfee; J P Coleman; E C Pesci
Journal:  Proc Natl Acad Sci U S A       Date:  2001-09-25       Impact factor: 11.205

Review 8.  Pharmacological inhibition of quorum sensing for the treatment of chronic bacterial infections.

Authors:  Morten Hentzer; Michael Givskov
Journal:  J Clin Invest       Date:  2003-11       Impact factor: 14.808

Review 9.  Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria.

Authors:  Grant D Geske; Jennifer C O'Neill; Helen E Blackwell
Journal:  Chem Soc Rev       Date:  2008-06-02       Impact factor: 54.564

10.  Modulation of bacterial quorum sensing with synthetic ligands: systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action.

Authors:  Grant D Geske; Jennifer C O'Neill; David M Miller; Margrith E Mattmann; Helen E Blackwell
Journal:  J Am Chem Soc       Date:  2007-10-10       Impact factor: 15.419
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