| Literature DB >> 10617084 |
I Ojima1, T Wang, M L Miller, S Lin, C P Borella, X Geng, P Pera, R J Bernacki.
Abstract
A series of second-generation taxoids bearing a substituent on the C-2-benzoyl group and modifications at C-3'/C-10 positions was synthesized. These taxoids exhibited 2-3 orders of magnitude higher potency than that of paclitaxel against drug-resistant human breast cancer cell lines. It is also noteworthy that three taxoids showed almost no difference in activity against drug-resistant and drug-sensitive cell lines, which are categorized as "advanced second generation taxoids".Entities:
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Year: 1999 PMID： 10617084 DOI： 10.1016/s0960-894x(99)00629-0
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823