Literature DB >> 10616523

The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias of Down syndrome.

D Malkin1, E J Brown, A Zipursky.   

Abstract

Sequence analysis of the p53 tumor suppressor gene was performed on diagnostic blood and bone marrow samples from nine children with Down syndrome and acute megakaryoblastic leukemia. p53 sequence alterations were not observed in any of seven cases of transient leukemia; however, samples from two of three patients with acute megakaryoblastic leukemia harbored sequence alterations. The acquisition of both mutations (Gly245Val and Arg72Pro) in the transformation from transient leukemia to overt acute megakaryoblastic leukemia suggests a functional role of mutant p53 in the evolution of this disease.

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Year:  2000        PMID： 10616523     DOI： 10.1016/s0165-4608(99)00072-2

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  10 in total

Review 1.  Evolution of myeloid leukemia in children with Down syndrome.

Authors:  Satoshi Saida
Journal:  Int J Hematol       Date:  2016-02-24       Impact factor: 2.490

2.  Myeloid Proliferations Associated with Down Syndrome.

Authors:  Alan B Cantor
Journal:  J Hematop       Date:  2014-12-14       Impact factor: 0.196

3.  The landscape of somatic mutations in Down syndrome-related myeloid disorders.

Authors:  Kenichi Yoshida; Tsutomu Toki; Yusuke Okuno; Rika Kanezaki; Yuichi Shiraishi; Aiko Sato-Otsubo; Masashi Sanada; Myoung-ja Park; Kiminori Terui; Hiromichi Suzuki; Ayana Kon; Yasunobu Nagata; Yusuke Sato; RuNan Wang; Norio Shiba; Kenichi Chiba; Hiroko Tanaka; Asahito Hama; Hideki Muramatsu; Daisuke Hasegawa; Kazuhiro Nakamura; Hirokazu Kanegane; Keiko Tsukamoto; Souichi Adachi; Kiyoshi Kawakami; Koji Kato; Ryosei Nishimura; Shai Izraeli; Yasuhide Hayashi; Satoru Miyano; Seiji Kojima; Etsuro Ito; Seishi Ogawa
Journal:  Nat Genet       Date:  2013-09-22       Impact factor: 38.330

Review 4.  Myeloid leukemia in Down syndrome.

Authors:  Irum Khan; Sébastien Malinge; John Crispino
Journal:  Crit Rev Oncog       Date:  2011

5.  MiR-1246: a new link of the p53 family with cancer and Down syndrome.

Authors:  Jun-Ming Liao; Xiang Zhou; Yu Zhang; Hua Lu
Journal:  Cell Cycle       Date:  2012-07-15       Impact factor: 4.534

Review 6.  Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome.

Authors:  Sébastien Malinge; Shai Izraeli; John D Crispino
Journal:  Blood       Date:  2009-01-12       Impact factor: 22.113

7.  Early lineage priming by trisomy of Erg leads to myeloproliferation in a Down syndrome model.

Authors:  Ashley P Ng; Yifang Hu; Donald Metcalf; Craig D Hyland; Helen Ierino; Belinda Phipson; Di Wu; Tracey M Baldwin; Maria Kauppi; Hiu Kiu; Ladina Di Rago; Douglas J Hilton; Gordon K Smyth; Warren S Alexander
Journal:  PLoS Genet       Date:  2015-05-14       Impact factor: 5.917

Review 8.  Familial Myelodysplastic/Acute Leukemia Syndromes-Myeloid Neoplasms with Germline Predisposition.

Authors:  Renata Lyrio Rafael Baptista; Anna Cláudia Evangelista Dos Santos; Luciana Mayumi Gutiyama; Cristiana Solza; Ilana Renault Zalcberg
Journal:  Front Oncol       Date:  2017-09-12       Impact factor: 6.244

9.  Unbalanced chromosome 1 abnormalities leading to partial trisomy 1q in four infants with Down syndrome and acute megakaryocytic leukemia.

Authors:  Maria Luiza Macedo Silva; Maria do Socorro Pombo-de-Oliveira; Susana C Raimondi; Hasmik Mkrtchyan; Eliana Abdelhay; Amanda Faria de Figueiredo; Mariana Tavares de Souza; Daniela Ribeiro Ney Garcia; Eliane Maria Soares de Ventura; Adriana Martins de Sousa; Thomas Liehr
Journal:  Mol Cytogenet       Date:  2009-02-19       Impact factor: 2.009

Review 10.  GATA family transcriptional factors: emerging suspects in hematologic disorders.

Authors:  Juehua Gao; Yi-Hua Chen; LoAnn C Peterson
Journal:  Exp Hematol Oncol       Date:  2015-10-06
  10 in total

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