OBJECTIVE: To explore whether HIV types 1 and 2 and CD4 cell count affect cervical neoplasia independent of human papillomavirus (HPV) in women with high or low numbers of sexual partners residing in Abidjan, Côte d'Ivoire. METHODS: The study population and methods are described in the companion paper. Additional methods include a Papanicolaou smear for cytological diagnosis and statistical analysis. RESULTS: In maternal women, both HIV-1 and high risk HPV were significant independent risk factors for squamous intraepithelial lesions (SIL) (adjusted odds ratio (OR) 11.0 (95% CI 1.1-112) and 5.4 (1.5-18.8), respectively). Only high levels of HPV DNA in the lavage were associated with SIL (OR 13.2 (3.6-47.8)) in the maternal group. In female sex workers, high risk HPV was significantly associated with SIL (OR 23.7 (4.4-126)); HIV seropositivity was not. Any positive level (high or low amounts) of HPV DNA was significantly associated with SIL in sex workers (ORs 15.9 (3.3-76) and 12.7 (3.6-44), respectively). There was no association of SIL with CD4 cell counts < or = 500 x 10(6)/l in HIV seropositive women from either group. CONCLUSION: HPV or HIV-1 infection independently affect cervical neoplasia in women with low numbers of sex partners.
OBJECTIVE: To explore whether HIV types 1 and 2 and CD4 cell count affect cervical neoplasia independent of human papillomavirus (HPV) in women with high or low numbers of sexual partners residing in Abidjan, Côte d'Ivoire. METHODS: The study population and methods are described in the companion paper. Additional methods include a Papanicolaou smear for cytological diagnosis and statistical analysis. RESULTS: In maternal women, both HIV-1 and high risk HPV were significant independent risk factors for squamous intraepithelial lesions (SIL) (adjusted odds ratio (OR) 11.0 (95% CI 1.1-112) and 5.4 (1.5-18.8), respectively). Only high levels of HPV DNA in the lavage were associated with SIL (OR 13.2 (3.6-47.8)) in the maternal group. In female sex workers, high risk HPV was significantly associated with SIL (OR 23.7 (4.4-126)); HIV seropositivity was not. Any positive level (high or low amounts) of HPV DNA was significantly associated with SIL in sex workers (ORs 15.9 (3.3-76) and 12.7 (3.6-44), respectively). There was no association of SIL with CD4 cell counts < or = 500 x 10(6)/l in HIV seropositive women from either group. CONCLUSION:HPV or HIV-1 infection independently affect cervical neoplasia in women with low numbers of sex partners.
Authors: C L Langley; E Benga-De; C W Critchlow; I Ndoye; M D Mbengue-Ly; J Kuypers; G Woto-Gaye; S Mboup; C Bergeron; K K Holmes; N B Kiviat Journal: AIDS Date: 1996-04 Impact factor: 4.177
Authors: M A Piper; S T Severin; S Z Wiktor; E R Unger; P D Ghys; D L Miller; I R Horowitz; A E Greenberg; W C Reeves; S D Vernon Journal: Sex Transm Infect Date: 1999-08 Impact factor: 3.519
Authors: S K Kjaer; E M de Villiers; B J Haugaard; R B Christensen; C Teisen; K A Møller; P Poll; H Jensen; B F Vestergaard; E Lynge Journal: Int J Cancer Date: 1988-04-15 Impact factor: 7.396
Authors: J Acs; A Hildesheim; W C Reeves; M Brenes; L Brinton; C Lavery; M E de la Guardia; J Godoy; W E Rawls Journal: Cancer Res Date: 1989-10-15 Impact factor: 12.701
Authors: J R Smith; V S Kitchen; M Botcherby; M Hepburn; C Wells; D Gor; S M Forster; J R Harris; P Steer; P Mason Journal: Br J Obstet Gynaecol Date: 1993-02
Authors: M Laga; J P Icenogle; R Marsella; A T Manoka; N Nzila; R W Ryder; S H Vermund; W L Heyward; A Nelson; W C Reeves Journal: Int J Cancer Date: 1992-01-02 Impact factor: 7.396
Authors: P J Kanki; K U Travers; S MBoup; C C Hsieh; R G Marlink; A Gueye-NDiaye; T Siby; I Thior; M Hernandez-Avila; J L Sankalé Journal: Lancet Date: 1994-04-16 Impact factor: 79.321
Authors: M A Piper; S T Severin; S Z Wiktor; E R Unger; P D Ghys; D L Miller; I R Horowitz; A E Greenberg; W C Reeves; S D Vernon Journal: Sex Transm Infect Date: 1999-08 Impact factor: 3.519
Authors: P Mayaud; D K Gill; H A Weiss; E Uledi; L Kopwe; J Todd; G ka-Gina; H Grosskurth; R J Hayes; D C Mabey; C J Lacey Journal: Sex Transm Infect Date: 2001-08 Impact factor: 3.519
Authors: Hilary K Whitham; Stephen E Hawes; Haitao Chu; J Michael Oakes; Alan R Lifson; Nancy B Kiviat; Papa Salif Sow; Geoffrey S Gottlieb; Selly Ba; Marie P Sy; Shalini L Kulasingam Journal: Cancer Epidemiol Biomarkers Prev Date: 2017-05-17 Impact factor: 4.254