Literature DB >> 10614992

The involvement of kallikrein-kinin system in diabetes type I (insulitis).

A Zuccollo1, M Navarro, M Frontera, F Cueva, M Carattino, O L Catanzaro.   

Abstract

Islet inflammation or insulitis is followed by selective destruction of the insulin secreting B-cell. Animal models of insulin-dependent diabetes mellitus (IDDM) have been used to characterize more fully insulitis, and our results with C57/BL/Ks mdb with low doses of streptozotocin (STZ) confirmed the disease. B1 receptor antagonist [Leu8]des-Arg9-BK has shown a significant effect on diabetic glycemia and renal control parameters. Compared to insulin, the drug was effective to prevent the insulitis and the renal damage. On the other hand, B2 receptor antagonist (HOE 140) and ACE-I (captopril) were only able to control the urinary diabetic proteinuria.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10614992     DOI： 10.1016/s0162-3109(99)00149-6

Source DB:  PubMed          Journal:  Immunopharmacology        ISSN： 0162-3109


  7 in total

1.  Description of the sphingolipid content and subspecies in the diabetic cornea.

Authors:  Shrestha Priyadarsini; Akhee Sarker-Nag; Jeremy Allegood; Charles Chalfant; Dimitrios Karamichos
Journal:  Curr Eye Res       Date:  2014-11-26       Impact factor: 2.424

2.  Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathy.

Authors:  Sébastien Talbot; Emna Chahmi; Jenny Pena Dias; Réjean Couture
Journal:  J Neuroinflammation       Date:  2010-06-29       Impact factor: 8.322

Review 3.  The kallikrein-kinin system as a regulator of cardiovascular and renal function.

Authors:  Nour-Eddine Rhaleb; Xiao-Ping Yang; Oscar A Carretero
Journal:  Compr Physiol       Date:  2011-04       Impact factor: 9.090

4.  Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B(1) and B(2) receptors.

Authors:  M Abdouh; S Talbot; R Couture; H M Hasséssian
Journal:  Br J Pharmacol       Date:  2008-03-03       Impact factor: 8.739

5.  Kinin B1 receptor in adipocytes regulates glucose tolerance and predisposition to obesity.

Authors:  Marcelo A Mori; Vicência Micheline Sales; Fabiana Louise Motta; Raphael Gomes Fonseca; Natalia Alenina; Dioze Guadagnini; Ines Schadock; Elton Dias Silva; Hugo A M Torres; Edson Lucas dos Santos; Charlles Heldan Castro; Vânia D'Almeida; Sandra Andreotti; Amanda Baron Campaña; Rogério A L Sertié; Mario J A Saad; Fabio Bessa Lima; Michael Bader; João Bosco Pesquero
Journal:  PLoS One       Date:  2012-09-14       Impact factor: 3.240

6.  The Dual Role of Kinin/Kinin Receptors System in Alzheimer's Disease.

Authors:  Bingyuan Ji; Qinqin Wang; Qingjie Xue; Wenfu Li; Xuezhi Li; Yili Wu
Journal:  Front Mol Neurosci       Date:  2019-10-01       Impact factor: 5.639

7.  Kinin B1 and B2 receptor deficiency protects against obesity induced by a high-fat diet and improves glucose tolerance in mice.

Authors:  Rafael L Morais; Elton D Silva; Vicência M Sales; Rafael Filippelli-Silva; Marcelo A Mori; Michael Bader; João B Pesquero
Journal:  Diabetes Metab Syndr Obes       Date:  2015-08-26       Impact factor: 3.168
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.